Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii
文献类型：期刊论文
| 作者 | Xiong, Juan1,2; Meng, Wei-Jia1,2; Zhang, Hai-Yan3 ; Zou, Yike4; Wang, Wen-Xuan5; Wang, Xin-Yi1,2; Yang, Qi-Lian1,2; Osman, Ezzat E. A.1,2,6; Hu, Jin-Feng1,2
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2019-06-01 |
| 卷号 | 162页码:183-192 |
| 关键词 | Huperzia fargesii Lycopodiaceae Lycopodium alkaloids Lycofargesiines anti-AChE |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2019.03.015 |
| 通讯作者 | Zhang, Hai-Yan(hzhang@simm.ac.cn) ; Yang, Qi-Lian(yangql@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn) |
| 英文摘要 | Six undescribed,Lycopodium alkaloids (LAs) comprising four lycodine-type (Iycofargesiines A-D), one lycopodine-type (lycofargesiine E), and a phlegmarine-type (lycofargesiine F), together with 16 known ones were isolated from the club moss Huperzia fargesii. Their structures and absolute configurations were determined by extensive spectroscopic methods, electronic circular dichroism (ECD) analysis, and density functional theory (DFT) calculations. (7S,8R,12R,13R)-Lycofargesiine A is a rare naturally occurring LA possessing an exocyclic double bond between C-15 and C-16, with ring A being a rare 2,3-dihyropyridone motif. Lycofargesiine D is an uncommon lycodine-type alkaloid featuring a unique N-acetylated tetrahydropyridinyl segment (ring A), whereas lycofargesiine F is the first phlegmarane-type LA bearing two nitrone moieties. In addition to the isolated huperzine A in this study, another two isolates (lycofargesiine C and 16-hydroxyhuperzine A) were also found to show inhibitory activities against acetylcholinesterase (AChE), with IC50 values of 8.63 and 5.18 mu M, respectively. |
| WOS关键词 | LYCODINE-TYPE ALKALOIDS ; CHEMISTRY ; SKELETON |
| 资助项目 | NSFC[81773599] ; NSFC[21772025] ; NSFC[21472021] ; National Science and Technology Major Project for New Drug Research and Development of MOST[2018ZX093050008-005] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000469157200018 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289591]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Hai-Yan; Yang, Qi-Lian; Hu, Jin-Feng |
| 作者单位 | 1.Fudan Univ, Minhang Hosp, Shanghai 201199, Peoples R China 2.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201199, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 4.Univ Penn, Dept Chem, 231 S 34 St, Philadelphia, PA 19104 USA 5.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 6.Theodor Bilharz Res Inst, Med Chem Lab, Kornaish El Nile St, Giza 12411, Egypt |
| 推荐引用方式 GB/T 7714 | Xiong, Juan,Meng, Wei-Jia,Zhang, Hai-Yan,et al. Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii[J]. PHYTOCHEMISTRY,2019,162:183-192. |
| APA | Xiong, Juan.,Meng, Wei-Jia.,Zhang, Hai-Yan.,Zou, Yike.,Wang, Wen-Xuan.,...&Hu, Jin-Feng.(2019).Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii.PHYTOCHEMISTRY,162,183-192. |
| MLA | Xiong, Juan,et al."Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii".PHYTOCHEMISTRY 162(2019):183-192. |
入库方式： OAI收割
来源：上海药物研究所
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