中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii

文献类型:期刊论文

作者Xiong, Juan1,2; Meng, Wei-Jia1,2; Zhang, Hai-Yan3; Zou, Yike4; Wang, Wen-Xuan5; Wang, Xin-Yi1,2; Yang, Qi-Lian1,2; Osman, Ezzat E. A.1,2,6; Hu, Jin-Feng1,2
刊名PHYTOCHEMISTRY
出版日期2019-06-01
卷号162页码:183-192
关键词Huperzia fargesii Lycopodiaceae Lycopodium alkaloids Lycofargesiines anti-AChE
ISSN号0031-9422
DOI10.1016/j.phytochem.2019.03.015
通讯作者Zhang, Hai-Yan(hzhang@simm.ac.cn) ; Yang, Qi-Lian(yangql@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要Six undescribed,Lycopodium alkaloids (LAs) comprising four lycodine-type (Iycofargesiines A-D), one lycopodine-type (lycofargesiine E), and a phlegmarine-type (lycofargesiine F), together with 16 known ones were isolated from the club moss Huperzia fargesii. Their structures and absolute configurations were determined by extensive spectroscopic methods, electronic circular dichroism (ECD) analysis, and density functional theory (DFT) calculations. (7S,8R,12R,13R)-Lycofargesiine A is a rare naturally occurring LA possessing an exocyclic double bond between C-15 and C-16, with ring A being a rare 2,3-dihyropyridone motif. Lycofargesiine D is an uncommon lycodine-type alkaloid featuring a unique N-acetylated tetrahydropyridinyl segment (ring A), whereas lycofargesiine F is the first phlegmarane-type LA bearing two nitrone moieties. In addition to the isolated huperzine A in this study, another two isolates (lycofargesiine C and 16-hydroxyhuperzine A) were also found to show inhibitory activities against acetylcholinesterase (AChE), with IC50 values of 8.63 and 5.18 mu M, respectively.
WOS关键词LYCODINE-TYPE ALKALOIDS ; CHEMISTRY ; SKELETON
资助项目NSFC[81773599] ; NSFC[21772025] ; NSFC[21472021] ; National Science and Technology Major Project for New Drug Research and Development of MOST[2018ZX093050008-005]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000469157200018
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/289591]  
专题中国科学院上海药物研究所
通讯作者Zhang, Hai-Yan; Yang, Qi-Lian; Hu, Jin-Feng
作者单位1.Fudan Univ, Minhang Hosp, Shanghai 201199, Peoples R China
2.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201199, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
4.Univ Penn, Dept Chem, 231 S 34 St, Philadelphia, PA 19104 USA
5.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
6.Theodor Bilharz Res Inst, Med Chem Lab, Kornaish El Nile St, Giza 12411, Egypt
推荐引用方式
GB/T 7714
Xiong, Juan,Meng, Wei-Jia,Zhang, Hai-Yan,et al. Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii[J]. PHYTOCHEMISTRY,2019,162:183-192.
APA Xiong, Juan.,Meng, Wei-Jia.,Zhang, Hai-Yan.,Zou, Yike.,Wang, Wen-Xuan.,...&Hu, Jin-Feng.(2019).Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii.PHYTOCHEMISTRY,162,183-192.
MLA Xiong, Juan,et al."Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii".PHYTOCHEMISTRY 162(2019):183-192.

入库方式: OAI收割

来源:上海药物研究所

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