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Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds

文献类型：期刊论文

作者Peng, Xiaofeng1,2; Zhang, Xiaofei1; Li, Shunyao1,2; Lu, Yunfu1,2; Lan, Lefu1,2; Yang, Chunhao1,2
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2019-06-07
卷号6期号:11页码:1775-1779
ISSN号2052-4129
DOI10.1039/c9qo00324j
通讯作者Lan, Lefu(llan@simm.ac.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要Herein, a simple and regioselective synthesis of (2-hydroxyphenyl)(3-(trifluoromethyl/ cyano/ phosphonate)- 1H-pyrazol-5-yl) methanones as pyrrolomycin analogues was reported. This reaction could proceed from 3-formylchromones and the corresponding diazo compounds by a silver-mediated one-pot cascade reaction under mild conditions with a broad substrate scope. Most of all, some products displayed potent antibacterial activities.
WOS关键词REGIOSELECTIVE SYNTHESIS ; BIOLOGICAL EVALUATION ; INSECTICIDAL CHLORFENAPYR ; DESIGN ; CYCLOADDITION ; FLUORINE ; FLOW
资助项目Science and Technology Commission of Shanghai Municipality[18431907100] ; Shanghai Sailing Program[17YF1423400]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000469257000004
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/289638]  
专题新药研究国家重点实验室
通讯作者Lan, Lefu; Yang, Chunhao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Peng, Xiaofeng,Zhang, Xiaofei,Li, Shunyao,et al. Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(11):1775-1779.
APA Peng, Xiaofeng,Zhang, Xiaofei,Li, Shunyao,Lu, Yunfu,Lan, Lefu,&Yang, Chunhao.(2019).Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds.ORGANIC CHEMISTRY FRONTIERS,6(11),1775-1779.
MLA Peng, Xiaofeng,et al."Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds".ORGANIC CHEMISTRY FRONTIERS 6.11(2019):1775-1779.

入库方式： OAI收割

来源：上海药物研究所

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