DCZ0801, a novel compound, induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma
文献类型：期刊论文
| 作者 | Zhang, Ting1; Li, Bo2; Feng, Qilin1; Xu, Zhijian2 ; Huang, Cheng1; Wu, Huiqun1; Chen, Zhangbo1; Hu, Liangning1; Gao, Lu1; Liu, Peng2
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| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
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| 出版日期 | 2019-05-01 |
| 卷号 | 51期号:5页码:517-523 |
| 关键词 | DCZ0801 multiple myeloma apoptosis cell cycle MAPK |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gmz033 |
| 通讯作者 | Shi, Jumei(shijumei@tongji.edu.cn) ; Zhu, Weiliang(wlzhu@simm.ac.cn) |
| 英文摘要 | Multiple myeloma (MM) is a refractory malignant hematological malignancy, and many therapeutic strategies have been developed to cure patients with MM. DCZ0801 is a compound that consists of oxophenamide and pterostilbene. The role of these compounds in hematological cancers such as MM has yet to be studied. In this study, we explored the potential mechanism of DCZ0801 action, its anti-tumor activity both in vitro and in vivo on MM. This study was carried out via cell cycle proliferation assay, apoptotic analysis, western blot analysis, and examination of xenotransplantation model of tumors. The in vitro studies revealed that DCZ0801 could inhibit cell proliferation and induce apoptosis by regulating both caspase-dependent and mitogen-activated protein kinase signaling pathways, inducing S-phase arrest of the cell cycle related to downregulation of CDK2, cyclin-A2, and CDC25A protein expression. The in vivo studies showed that DCZ0801 could significantly reduce the size of the tumors in nude mice. Our results demonstrated that DCZ0801 may emerge as the new therapeutic option for the patient with MM. |
| WOS关键词 | IN-VITRO ; PTEROSTILBENE ; CANCER ; PROLIFERATION ; P38 ; ACTIVATION ; INDUCTION ; SURVIVAL ; ERK1/2 |
| 资助项目 | National Natural Science Foundation of China[81670194] ; National Natural Science Foundation of China[81529001] ; National Natural Science Foundation of China[81570190] ; National Natural Science Foundation of China[81870158] ; National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2018ZX09711002] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000469431000008 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289642]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shi, Jumei; Zhu, Weiliang |
| 作者单位 | 1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Hematol, Shanghai 200072, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ting,Li, Bo,Feng, Qilin,et al. DCZ0801, a novel compound, induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2019,51(5):517-523. |
| APA | Zhang, Ting.,Li, Bo.,Feng, Qilin.,Xu, Zhijian.,Huang, Cheng.,...&Zhu, Weiliang.(2019).DCZ0801, a novel compound, induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,51(5),517-523. |
| MLA | Zhang, Ting,et al."DCZ0801, a novel compound, induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 51.5(2019):517-523. |
入库方式： OAI收割
来源：上海药物研究所
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