Structural Elucidation and Total Synthesis of Three 9-Norlignans from Curculigo capitulata
文献类型：期刊论文
| 作者 | Li, Song1; Yu, Jin-Hai2; Fan, Yao-Yue2; Liu, Qun-Fang2 ; Li, Zhan-Chao1; Xie, Zhi-Xiang1; Li, Ying1; Yue, Jian-Min2
|
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2019-05-03 |
| 卷号 | 84期号:9页码:5195-5202 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.9b00170 |
| 通讯作者 | Li, Ying(liying@lzu.edu.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Capitulactones A-C, three unprecedented 9-norlignans featuring a unique 3,5-dihydrofuro[2,3-d]oxepin7-(2H)-one scaffold, were isolated from the roots of Curculigo capitulata. Their structures with absolute configurations were unambiguously established by a combination of spectroscopic data, ECD analysis, and total synthesis. Biomimetic total syntheses of three pairs of the corresponding enantiomers were achieved in 9-10 steps with overall yields of 14.8, 12.7, and 10.3%, respectively. Notably, the unique scaffold of the common western hemisphere of the molecules was constructed by using the oxidation-reduction strategy from benzodihydrofuran. |
| WOS关键词 | NORLIGNAN GLUCOSIDES ; RHIZOMES |
| 资助项目 | National Natural Science Foundation[21772213] ; National Natural Science Foundation[21772079] ; National Natural Science Foundation[21472078] ; Drug Innovation Major Project of the P. R. China[2018ZX09711001-001-005] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000467319600024 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289689]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Ying; Yue, Jian-Min |
| 作者单位 | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Song,Yu, Jin-Hai,Fan, Yao-Yue,et al. Structural Elucidation and Total Synthesis of Three 9-Norlignans from Curculigo capitulata[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(9):5195-5202. |
| APA | Li, Song.,Yu, Jin-Hai.,Fan, Yao-Yue.,Liu, Qun-Fang.,Li, Zhan-Chao.,...&Yue, Jian-Min.(2019).Structural Elucidation and Total Synthesis of Three 9-Norlignans from Curculigo capitulata.JOURNAL OF ORGANIC CHEMISTRY,84(9),5195-5202. |
| MLA | Li, Song,et al."Structural Elucidation and Total Synthesis of Three 9-Norlignans from Curculigo capitulata".JOURNAL OF ORGANIC CHEMISTRY 84.9(2019):5195-5202. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。