VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism
文献类型：期刊论文
| 作者 | Tang, Bo1,2; Wu, Jilin3,4; Zhu, Michael X.3,5; Sun, Xuemei2; Liu, Jingjing2; Xie, Rui2,6; Dong, Tobias Xiao1; Xiao, Yufeng2; Carethers, John M.7; Yang, Shiming2 |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2019-05-16 |
| 卷号 | 38期号:20页码:3946-3961 |
| ISSN号 | 0950-9232 |
| DOI | 10.1038/s41388-019-0709-6 |
| 通讯作者 | Yang, Shiming(shimingyang@yahoo.com) ; Dong, Hui(h2dong@ucsd.edu) |
| 英文摘要 | Although VPAC1 and its ligand vasoactive intestinal peptide (VIP) are important in gastrointestinal physiology, their involvements in progression of gastrointestinal tumor have not been explored. Here, we found that higher expression of VIP/VPAC1 was observed in gastric cancer compared to the adjacent normal tissues. The increased expression of VIP/VPAC1 in gastric cancer correlated positively with invasion, tumor stage, lymph node, distant metastases, and poor survival. Moreover, high expression of VIP and VPAC1, advanced tumor stage and distant metastasis were independent prognostic factors. VPAC1 activation by VIP markedly induced TRPV4-mediated Ca2+ entry, and eventually promoted gastric cancer progression in a Ca2+ signaling-dependent manner. Inhibition of VPAC1 and its signaling pathway could block the progressive responses. VPAC1/TRPV4/Ca2+ signaling in turn enhanced the expression and secretion of VIP in gastric cancer cells, enforcing a positive feedback regulation mechanism. Taken together, our study demonstrate that VPAC1 is significantly overexpressed in gastric cancer and VPAC1/TRPV4/Ca2+ signaling axis could enforce a positive feedback regulation in gastric cancer progression. VIP/VPAC1 may serve as potential prognostic markers and therapeutic targets for gastric cancer. |
| WOS关键词 | VASOACTIVE-INTESTINAL-PEPTIDE ; CELL-PROLIFERATION ; CA2+ ; VIP ; RECEPTOR ; ACTIVATION ; OVEREXPRESSION ; EXPRESSION ; SECRETION ; CATENIN |
| 资助项目 | National Key Research and Development Program of China[2016YFC1302200] ; National Natural Science Foundation of China[81602577] ; Basic Science and Frontier Technology Research Project of Chongqing[cstc2017jcyjAX0149] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000468035600013 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289785]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yang, Shiming; Dong, Hui |
| 作者单位 | 1.Univ Calif San Diego, Sch Med, Dept Med, San Diego, CA 92103 USA 2.Third Mil Med Univ, Xinqiao Hosp, Dept Gastroenterol, Chongqing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA 6.Zunyi Med Coll, Affiliated Hosp, Dept Gastroenterol, Zunyi, Peoples R China 7.Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA |
| 推荐引用方式 GB/T 7714 | Tang, Bo,Wu, Jilin,Zhu, Michael X.,et al. VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism[J]. ONCOGENE,2019,38(20):3946-3961. |
| APA | Tang, Bo.,Wu, Jilin.,Zhu, Michael X..,Sun, Xuemei.,Liu, Jingjing.,...&Dong, Hui.(2019).VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism.ONCOGENE,38(20),3946-3961. |
| MLA | Tang, Bo,et al."VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism".ONCOGENE 38.20(2019):3946-3961. |
入库方式： OAI收割
来源：上海药物研究所
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