Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives
文献类型：期刊论文
| 作者 | Yang, Li2; Liu, Feifei2,3; Tong, Xiankun2 ; Hoffmann, Daniel1; Zuo, Jianping2; Lu, Mengji4
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| 刊名 | ACS INFECTIOUS DISEASES
 |
| 出版日期 | 2019-05-01 |
| 卷号 | 5期号:5页码:713-724 |
| 关键词 | hepatitis B virus HBV core protein HBcAg capsid assembly capsid assembly modulators (CAMs) antiviral therapy clinical trials |
| ISSN号 | 2373-8227 |
| DOI | 10.1021/acsinfecdis.8b00337 |
| 通讯作者 | Lu, Mengji(mengji.li@uni-due.de) |
| 英文摘要 | On the basis of the recent advance of basic research on molecular biology of hepatitis B virus (HBV) infection, novel antiviral drugs targeting various steps of the HBV life cycle have been developed in recent years. HBV nucleocapsid assembly is now recognized as a hot target for anti-HBV drug development. Structural and functional analysis of HBV nucleocapsid allowed rational design and improvement of small molecules with the ability to interact with the components of HBV nucleocapsid and modulate the viral nucleocapsid assembly process. Prototypes of small molecule modulators targeting HBV nucleocapsid assembly are being preclinically tested or have moved forward in clinical trials, with promising results. This Review summarizes the recent advances in the approach to develop antiviral drugs based on the modulation of HBV nucleocapsid assembly. The antiviral mechanisms of small molecule modulators beyond the capsid formation and the potential implications will be discussed. |
| WOS关键词 | CORE PROTEIN ; PEGYLATED INTERFERON ; CRYSTAL-STRUCTURE ; NVR 3-778 ; REPLICATION ; DERIVATIVES ; INHIBITORS ; PARTICLES ; GENOME ; COMBINATION |
| 资助项目 | National Science Foundation of Shanghai[DFG TRR60] ; [17ZR1436400] |
| WOS研究方向 | Pharmacology & Pharmacy ; Infectious Diseases |
| 语种 | 英语 |
| WOS记录号 | WOS:000468015100007 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289793]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lu, Mengji |
| 作者单位 | 1.Univ Duisburg Essen, Inst Bioinformat, Univ Str 1, D-45117 Essen, Germany 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Lab Immunopharmacol, Zhangjiang Hitech Pk,555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Hufelandstr 55, D-45122 Essen, Germany |
| 推荐引用方式 GB/T 7714 | Yang, Li,Liu, Feifei,Tong, Xiankun,et al. Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives[J]. ACS INFECTIOUS DISEASES,2019,5(5):713-724. |
| APA | Yang, Li,Liu, Feifei,Tong, Xiankun,Hoffmann, Daniel,Zuo, Jianping,&Lu, Mengji.(2019).Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives.ACS INFECTIOUS DISEASES,5(5),713-724. |
| MLA | Yang, Li,et al."Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives".ACS INFECTIOUS DISEASES 5.5(2019):713-724. |
入库方式： OAI收割
来源：上海药物研究所
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