中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
热门
Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade

文献类型：期刊论文

作者Zhou, Fangyuan2,3,4; Feng, Bing1,2,3; Yu, Haijun2,3; Wang, Dangge1,2,3; Wang, Tingting1,2,3; Ma, Yuting5,6,7; Wang, Siling4; Li, Yaping2,3
刊名ADVANCED MATERIALS
出版日期2019-04-05
卷号31期号:14页码:11
关键词cancer immunotherapy CD47 blockade immunogenic cell death prodrug vesicles tumor microenvironment
ISSN号0935-9648
DOI10.1002/adma.201805888
通讯作者Yu, Haijun(hjyu@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Chemoimmunotherapy is reported to activate a robust T cell antitumor immune response by triggering immunogenic cell death (ICD), which has initiated a number of clinical trials. However, current chemoimmunotherapy is restricted to a small fraction of patients due to low drug delivery efficacy and immunosuppression within the tumor microenvironment. A tumor microenvironment-activatable prodrug vesicle for cancer chemoimmunotherapy using ICD is herein reported. The prodrug vesicles are engineered by integrating an oxaliplatin (OXA) prodrug and PEGylated photosensitizer (PS) into a single nanoplatform, which show tumor-specific accumulation, activation, and deep penetration in response to the tumoral acidic and enzymatic microenvironment. It is demonstrated that codelivery of OXA prodrug and PS can trigger ICD of the tumor cells by immunogenic cells killing. The combination of prodrug vesicle-induced ICD with (I) over cap +/- CD47-mediated CD47 blockade further facilitates dendritic cell (DC) maturation, promotes antigen presentation by DCs, and eventually propagates the antitumor immunity of ICD. CD47 blockade and ICD induction efficiently inhibit the growth of both primary and abscopal tumors, suppress tumor metastasis, and prevent tumor recurrence. Collectively, these results imply that boosting antitumor immunity using ICD induction and suppressing tumor immune evasion via CD47 blockade might be promising for improved cancer chemoimmunotherapy.
WOS关键词THERAPY ; IMMUNOTHERAPY ; CHEMOTHERAPY ; SURVIVAL ; TARGET
资助项目National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81722037] ; Strategic Priority Research Program of CAS[XDA12050307] ; Natural Science Foundation of Jiangsu Province[BK20170006] ; Natural Science Foundation of Jiangsu Province[BK20160379]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000467974100001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/289823]  
专题新药研究国家重点实验室
通讯作者Yu, Haijun; Li, Yaping
作者单位1.Chinese Acad Sci UCAS, Beijing 100049, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China
5.Chinese Acad Med Sci, Ctr Syst Med, Inst Basic Med Sci, Beijing 100005, Peoples R China
6.Peking Union Med Coll, Beijing 100005, Peoples R China
7.Suzhou Inst Syst Med, Suzhou 215123, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Fangyuan,Feng, Bing,Yu, Haijun,et al. Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade[J]. ADVANCED MATERIALS,2019,31(14):11.
APA Zhou, Fangyuan.,Feng, Bing.,Yu, Haijun.,Wang, Dangge.,Wang, Tingting.,...&Li, Yaping.(2019).Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade.ADVANCED MATERIALS,31(14),11.
MLA Zhou, Fangyuan,et al."Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade".ADVANCED MATERIALS 31.14(2019):11.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。