Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide
文献类型：期刊论文
| 作者 | Hu, Xiaoxiao3,4; Wang, Caifen3; Wang, Lebing3; Liu, Zhaoxin5; Wua, Li3; Zhang, Guoqing3; Yu, Lin3; Ren, Xiaohong3; York, Peter1,3; Sun, Lixin4 |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2019-06-10 |
| 卷号 | 564页码:153-161 |
| 关键词 | gamma-Cyclodextrin metal-organic framework Dry powder inhalation Budesonide Cholesterol In vivo fluorescence imaging |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2019.04.030 |
| 通讯作者 | Sun, Lixin(slx04@163.com) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Li, Haiyan(lihaiyan821005@163.com) |
| 英文摘要 | It is essential to optimize a carrier of dry powder inhalation (DPI) for the aerodynamic deposition in vitro to achieve pulmonary delivery of drug molecules in vivo. In this study, neutralized nanoporous gamma-cyclodextrin metal-organic framework (CD-MOF) crystals with cubic morphology and uniform inhalation size were developed and modified as a DPI carrier for budesonide (BUD). Cholesterol (CHO) and leucine (LEU)-poloxamer were used to modify the CD-MOF powder for the improvement of flowability and particle aerodynamic behaviour, for which the particle size distribution, Carr's index and in vitro pulmonary deposition were assessed. Compared to CD-MOF or LEU-CD-MOF-BUD, CHO-CD-MOF had a superior mass median aerodynamic diameter (4.35 +/- 0.04 mu m) and inhalable performance (fine particle fraction of 30.60 +/- 0.76%), which were maintained after budesonide loading (4.47 +/- 0.30 mu m, 24.95 +/- 4.33%). The crystallinity, cytotoxicity and in vivo deposition of drug loaded samples (CHO-CD-MOF-BUD) were then investigated by powder X-ray diffraction (PXRD), cell viability study, in vivo fluorescence imaging and pharmacokinetic studies in rats. The characteristic PXRD crystallinity peaks of budesonide disappeared after being loaded into CHO-CD-MOF, potentially indicating the molecular incorporation of budesonide into the pores of CD-MOF. The cell viability of A549 cell was more than 90% for CHO-CD-MOF-BUD as a result of the good biocompatibility of CD-MOF. When Rhodamine B was carried by the DPI particles, the fluorescence signal at the lung tissue was markedly improved after cholesterol modification compared with CD-MOF, whilst the bioavailability of CHO-CD-MOF-BUD in rat was equivalent with that of the commercial product of Pulmicort Turbuhaler. Therefore, the CD-MOF powders modified by cholesterol can be used as a promising inhalable carrier for pulmonary delivery of drugs with small dose. |
| WOS关键词 | DRY POWDER INHALATION ; DRUG ; NANOCARRIERS ; FORMULATION ; CHOLESTEROL ; STRATEGY |
| 资助项目 | Key Program for International Science and Technology Cooperation Projects of China[2016YFE0125100] ; Opening Project of Zhejiang Provincial First-rate Subject from Zhejiang Chinese Medical University[Ya2017006] ; Research Foundation of the Shanghai Institute of Materia Medica[CASIMM0120182001] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000467905200015 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289827]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Sun, Lixin; Zhang, Jiwen; Li, Haiyan |
| 作者单位 | 1.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England 2.Zhejiang Chinese Univ Med, Hangzhou 310053, Zhejiang, Peoples R China 3.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 5.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiaoxiao,Wang, Caifen,Wang, Lebing,et al. Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2019,564:153-161. |
| APA | Hu, Xiaoxiao.,Wang, Caifen.,Wang, Lebing.,Liu, Zhaoxin.,Wua, Li.,...&Li, Haiyan.(2019).Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide.INTERNATIONAL JOURNAL OF PHARMACEUTICS,564,153-161. |
| MLA | Hu, Xiaoxiao,et al."Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide".INTERNATIONAL JOURNAL OF PHARMACEUTICS 564(2019):153-161. |
入库方式： OAI收割
来源：上海药物研究所
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