Wenshen Zhuanggu formula mitigates breast cancer bone metastasis through the signaling crosstalk among the Jagged1/Notch, TGF-beta and IL-6 signaling pathways
文献类型：期刊论文
| 作者 | Wu, Chunyu2; Chen, Mingcang1,3; Sun, Zhenping2; Ye, Yiyi4; Han, Xianghui4; Qin, Yuenong2; Liu, Sheng2,4 |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2019-03-25 |
| 卷号 | 232页码:145-154 |
| 关键词 | Wenshen Zhuanggu formula Jagged1/Notch signaling TGF-beta IL-6 Breast cancer Bone metastasis |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2018.12.023 |
| 通讯作者 | Qin, Yuenong(frank_yching@aliyun.com) ; Liu, Sheng(sliu_tcm@163.com) |
| 英文摘要 | Ethnopharmacological relevance: Advanced breast cancer frequently metastasizes to the bone, resulting in patient morbidity and mortality. The interaction of tumor cells with osteoclasts and osteoblasts seriously affects the occurrence and development of bone metastasis in breast cancer. The signaling crosstalk among the Jagged1/Notch, TGF-beta and IL-6 signaling pathways plays a significant role in the context of bone metastasis. Aim of the study: Although Wenshen Zhuanggu (WSZG) formula efficiently decreased the risk of bone metastases in tumor-bearing mice, it remains unclear how WSZG formula regulates the interaction of cancer cells with osteoclasts and osteoblasts in bone metastasis of breast cancer. Materials and methods: In this study, we investigated the role of WSZG formula in the progress of bone metastasis in breast cancer and focused on the cell-cell interactions of tumor cells with osteoclasts and osteoblasts. Western blotting and quantitative real-time PCR were utilized to evaluate the inhibitory activities of WSZG formula on Jagged1 expression both in vivo and in vitro. Osteoblast co-culture and osteoclastogenesis co-culture were applied to analyze the effects of WSZG formula on the interaction of tumor cells with osteoclasts and osteoblasts. A breast cancer xenograft model was also used to test the inhibitory effects of WSZG formula on bone metastasis in breast cancer. Results: WSZG formula decreased Jagged1 expression in osteolytic lesions in the breast cancer xenograft model. Additionally, WSZG formula decreased Jagged1 expression in tumor cell culture alone or co-culture with pre-osteoclasts and osteoblasts. In addition, WSZG formula decreased Jagged1 expression in Jagged1-overexpressing tumor cells. Conclusion: The results of this study suggest that WSZG formula mitigates breast cancer bone metastasis through the Jagged1/Notch signaling pathway mediated by TGF-beta and IL-6. |
| WOS关键词 | NOTCH |
| 资助项目 | National Natural Science Foundation of China[81704075] ; National Natural Science Foundation of China[81603629] ; Natural Science Foundation of Shanghai[17ZR1430700] ; Foundation of Shanghai Municipal Commission of Health and Family Planning[20164Y0064] ; Shanghai Hospital Development Center[16CR2028B] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000467003000016 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289870]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Qin, Yuenong; Liu, Sheng |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Breast Surg Integrated Tradit & Western Med, 725 South Wanping Rd, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Pharmacol Lab Tradit Chinese Med, 725 South Wanping Rd, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Chunyu,Chen, Mingcang,Sun, Zhenping,et al. Wenshen Zhuanggu formula mitigates breast cancer bone metastasis through the signaling crosstalk among the Jagged1/Notch, TGF-beta and IL-6 signaling pathways[J]. JOURNAL OF ETHNOPHARMACOLOGY,2019,232:145-154. |
| APA | Wu, Chunyu.,Chen, Mingcang.,Sun, Zhenping.,Ye, Yiyi.,Han, Xianghui.,...&Liu, Sheng.(2019).Wenshen Zhuanggu formula mitigates breast cancer bone metastasis through the signaling crosstalk among the Jagged1/Notch, TGF-beta and IL-6 signaling pathways.JOURNAL OF ETHNOPHARMACOLOGY,232,145-154. |
| MLA | Wu, Chunyu,et al."Wenshen Zhuanggu formula mitigates breast cancer bone metastasis through the signaling crosstalk among the Jagged1/Notch, TGF-beta and IL-6 signaling pathways".JOURNAL OF ETHNOPHARMACOLOGY 232(2019):145-154. |
入库方式： OAI收割
来源：上海药物研究所
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