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Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging

文献类型：期刊论文

作者Zhang, Chao4; Wang, Guanzhen5,6; Han, Hai-Hao1,2; Hu, Xi-Le1,2; Field, Robert A.3; Chen, Guo-Rong1,2; Li, Jia5; Ye, Bing4; He, Xiao-Peng1,2; Zang, Yi5
刊名FRONTIERS IN CHEMISTRY
出版日期2019-05-08
卷号7页码:7
关键词fluorescence precision imaging activatable receptor
ISSN号2296-2646
DOI10.3389/fchem.2019.00294
通讯作者Ye, Bing(13583184890@163.com) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Zang, Yi(yzang@simm.ac.cn)
英文摘要The construction of targeted and activatable materials can largely improve the precision of disease diagnosis and therapy. However, the currently developed systems either target a transmembrane antigen or are activatable to release imaging and/or therapeutic reagents intracellularly. Here, we develop a simple thin-layer glycomaterial through the self-assembly between fluorescent glycoprobes, in which the carbohydrate-targeting reagent and the fluorophore are linked to each other by polyethylene glycol with a suitable chain length, and thin-layer manganese dioxide. The fluorogenic material developed is both capable of targeting a transmembrane glycoprotein receptor and fluorescently activatable by intracellular biothiols. The shell thickness of the material was determined to be important for achieving the biothiol-induced activation of fluorescence. This research might provide insight into the development of precision-enhanced self-assembled materials for disease theranostics.
WOS关键词MNO2 ; NANOSHEETS
资助项目National Natural Science Foundation of China[21722801] ; National Natural Science Foundation of China[21776078] ; National Natural Science Foundation of China[81671739] ; National Natural Science Foundation of China[81673489] ; National Natural Science Foundation of China[81125023] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; International Cooperation Project[16430724100]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000467292000001
出版者FRONTIERS MEDIA SA
源URL[http://119.78.100.183/handle/2S10ELR8/289928]  
专题新药研究国家重点实验室
通讯作者Ye, Bing; He, Xiao-Peng; Zang, Yi
作者单位1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai, Peoples R China
2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai, Peoples R China
3.Norwich Res Pk, Dept Biol Chem, John Innes Ctr, Norwich, Norfolk, England
4.Jinan Childrens Hosp, Emergency Dept, Jinan, Shandong, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Chao,Wang, Guanzhen,Han, Hai-Hao,et al. Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging[J]. FRONTIERS IN CHEMISTRY,2019,7:7.
APA Zhang, Chao.,Wang, Guanzhen.,Han, Hai-Hao.,Hu, Xi-Le.,Field, Robert A..,...&Zang, Yi.(2019).Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging.FRONTIERS IN CHEMISTRY,7,7.
MLA Zhang, Chao,et al."Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging".FRONTIERS IN CHEMISTRY 7(2019):7.

入库方式： OAI收割

来源：上海药物研究所

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