Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles
文献类型：期刊论文
| 作者 | Wu, Chenglin1,2,3; Zhou, Jianhui2,3; He, Guoxue2,3; Li, Huihui2,3; Yang, Qiaolan2,3; Wang, Run2,3; Zhou, Yu2,3 ; Liu, Hong1,2,3
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2019-04-21 |
| 卷号 | 6期号:8页码:1183-1188 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c9qo00048h |
| 通讯作者 | Zhou, Yu(zhouyu@simm.ac.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | Ruthenium-catalyzed selective C-H bond activation of imidamides and annulation of sulfoxonium ylides were achieved, which afforded a series of 3-ketoindole derivatives in good yields, with good functional group compatibility. The catalytic system generated an indole scaffold by C-N and C-S bond cleavage. This reaction constitutes the first intermolecular coupling of ylides with arenes to afford a 3-ketoindole skeleton by ruthenium-catalyzed C-H activation and annulation cascade. |
| WOS关键词 | CATALYZED SYNTHESIS ; ASYMMETRIC EPOXIDATION ; INDOLE-DERIVATIVES ; PROPARGYL ALCOHOLS ; 3+2 ANNULATION ; N BOND ; RUTHENIUM ; CYCLIZATION ; ACYLATION ; ANILINES |
| 资助项目 | National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027] ; National S&T Major Projects[2015ZX09103003] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040217] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000465285100015 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289953]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Yu; Liu, Hong |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Chenglin,Zhou, Jianhui,He, Guoxue,et al. Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(8):1183-1188. |
| APA | Wu, Chenglin.,Zhou, Jianhui.,He, Guoxue.,Li, Huihui.,Yang, Qiaolan.,...&Liu, Hong.(2019).Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles.ORGANIC CHEMISTRY FRONTIERS,6(8),1183-1188. |
| MLA | Wu, Chenglin,et al."Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles".ORGANIC CHEMISTRY FRONTIERS 6.8(2019):1183-1188. |
入库方式： OAI收割
来源：上海药物研究所
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