Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta[2,1-b:3,4-b ']diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent
文献类型：期刊论文
| 作者 | Peng, Lei1,2; Zhang, Xiaofei1; Yang, Chunhao1,2
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 24期号:5页码:13 |
| 关键词 | phenyliodine(III)bis(trifluoroacetate) cyclohepta[2,1-b:3,4-b ']diindole intramolecular oxidative coupling |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules24050960 |
| 通讯作者 | Zhang, Xiaofei(xiaofeizhang@simm.ac.cn) ; Yang, Chunhao(chyang@simm.ac.cn) |
| 英文摘要 | Bisindolyl alkaloids represent a large family of natural and synthetic products that display various biological activities. Among the bisindole compounds, 6,7,12,13-tetrahydro-5H-cyclohepta[2,1-b:3,4-b']diindoles have received little attention. Only two methods have been developed for the construction of the 6,7,12,13-tetrahydro-5H-cyclohepta[2,1-b: 3,4-b'] diindole scaffold thus far, including the classical Fischer indole synthesis conducted by reacting indole-fused cycloheptanone and hydrazines, and the condensation reaction to build the seven-membered ring. Here, we report for the first time a new route to synthesize 6,7,12,13-tetrahydro-5H-cyclohepta[2,1-b: 3,4-b'] diindoles through intramolecular oxidative coupling of 1,3-di(1H-indol-3-yl)propanes in the presence of PIFA, DDQ and TMSCl with moderate to excellent yields. |
| WOS关键词 | BIOLOGICAL EVALUATION ; COUPLING REACTION ; RAPID ACCESS ; BISINDOLE ; REBECCAMYCIN ; COMBINATION ; ANALOGS |
| 资助项目 | Shanghai Sailing Program[17YF1423400] ; China Postdoctoral Science Foundation[2017M621572] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000462662900136 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290031]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Xiaofei; Yang, Chunhao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Lei,Zhang, Xiaofei,Yang, Chunhao. Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta[2,1-b:3,4-b ']diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent[J]. MOLECULES,2019,24(5):13. |
| APA | Peng, Lei,Zhang, Xiaofei,&Yang, Chunhao.(2019).Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta[2,1-b:3,4-b ']diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent.MOLECULES,24(5),13. |
| MLA | Peng, Lei,et al."Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta[2,1-b:3,4-b ']diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent".MOLECULES 24.5(2019):13. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。