Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting
文献类型：期刊论文
| 作者 | He, Yaping2,3; Xu, Jian2,3; Sun, Xian2,3; Ren, Xiaohong3; Maharjan, Abi2,3; York, Peter4; Su, Yong1; Li, Haiyan2,3 ; Zhang, Jiwen2,3
|
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2019 |
| 卷号 | 9期号:9页码:2489-2504 |
| 关键词 | cuboidal cyclodextrin frameworks shape control activated platelets hemostasis injured vessel targeting |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.31159 |
| 通讯作者 | Su, Yong(ysu@fd-zj.com) ; Li, Haiyan(lihaiyan821005@163.com) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Rationale: Targeted delivery of therapeutic drugs or imaging agents to injured blood vessels via nanocarriers is likely to be dependent on the particle shape, yet cubic nanoparticle carriers have not been reported for vascular targeting. Here, we demonstrate that cuboidal cyclodextrin frameworks possess superior hemostasis effect and injured vessels targeting compared with spherical counterpart. Methods: Cuboidal and biocompatible y-cyclodextrin metal-organic frameworks (CD-MOFs) are synthesized, tethered via crosslinking and surface modification with GRGDS peptide (GS5-MOFs). The specific interactions of cubic GS5-MOF nanoparticles with activated platelets were investigated by in vitro platelet aggregation assay and atomic force microscopy measurements (AFM). The hemostatic capacity and injured vessel targeting efficacy were evaluated in vivo. Results: Cuboidal GS5-MOF nanoparticles exhibit enhanced adhesion and aggregation with activated platelets in vitro under static condition and a physiologically relevant flow environment. The cubic GS5-MOF nanoparticles show efficient hemostatic effects with bleeding time and blood loss decrease of 90% and strong injured vessel targeting in vivo, markedly superior to spherical gamma-CD nanosponges with the same chemical composition. Conclusions: These results clearly highlight the contribution of the cuboidal shape of GS5-MOFs to the enhanced aggregation of activated platelets and high targeting to damaged vessels. The cuboidal nanoparticle system provides an innovative delivery platform for the treatment and diagnosis of vascular diseases. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; DRUG ; NANOPARTICLES ; SHAPE ; STRATEGIES ; PLATELETS ; PLATFORMS ; PARTICLES ; DELIVERY ; CARRIERS |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; Key Program for International Science and Technology Cooperation Projects of China[2016YFE0125100] ; Research Foundation of the Shanghai Institute of Materia Medica[CASIMM0120182001] ; National Natural Science Foundation of China[81573392] ; National Natural Science Foundation of China[81430087] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000465285400005 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290034]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Su, Yong; Li, Haiyan; Zhang, Jiwen |
| 作者单位 | 1.Shanghai Fudan Zhangjiang Biopharmaceut Co Ltd, Shanghai 201210, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England |
| 推荐引用方式 GB/T 7714 | He, Yaping,Xu, Jian,Sun, Xian,et al. Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting[J]. THERANOSTICS,2019,9(9):2489-2504. |
| APA | He, Yaping.,Xu, Jian.,Sun, Xian.,Ren, Xiaohong.,Maharjan, Abi.,...&Zhang, Jiwen.(2019).Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting.THERANOSTICS,9(9),2489-2504. |
| MLA | He, Yaping,et al."Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting".THERANOSTICS 9.9(2019):2489-2504. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。