Analytical methods and biological activities of Panax notoginseng saponins: Recent trends
文献类型：期刊论文
| 作者 | Xu, Congcong1,6; Wang, Weiwei1,6; Wang, Bing1,7; Zhang, Tong1,6; Cui, Xiuming2; Pu, Yiqiong1; Li, Ning3,4,5 |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2019-05-23 |
| 卷号 | 236页码:443-465 |
| 关键词 | Panax notoginseng Analysis HPLC Pharmacology Toxicity |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2019.02.035 |
| 通讯作者 | Pu, Yiqiong(puyiqiong@shutcm.edu.cn) ; Li, Ning(mailtolining@gmail.com) |
| 英文摘要 | Ethnopharmacological relevance: Panax notoginseng (Burk.) F. H. Chen, also called Sanqi, is a widely used traditional Chinese medicine, which has long history used as herbal medicines. It is currently an important medicinal material in China, holding the first place in the sale volume of the whole patent medicines market in China, and the market size of the single species has exceeded 10 billion yuan. In addition, P. notoginseng is an important constituent part of many famous Chinese patent medicines, such as Compound Danshen Dripping Pills and Yunnan Baiyao. P. notoginseng saponins (PNSs), which are the major active components of P. notoginseng, are a kind of chemical mixture containing different dammarane-type saponins. Many studies show that PNSs have been extensively used in medical research or applications, such as atherosclerosis, diabetes, acute lung injury, cancer, and cardiovascular diseases. In addition, various PNS preparations, such as injections and capsules, have been made commercially available and are widely applied in clinical practice. Aim of the review: Since the safety and efficacy of compounds are related to their qualitative and quantitative analyses, this review briefly summarizes the analytic approaches for PNSs and their biological effects developed in the last decade. Methodology: This review conducted a systematic search in electronic databases, such as Pubmed, Google Scholar, SciFinder, ISI Web of Science, and CNKI, since 2009. The information provided in this review is based on peer-reviewed papers and patents in either English or Chinese. Results: At present, the chromatographic technique remains the most extensively used approach for the identification or quantitation of PNSs, coupled with different detectors, among which the difference mainly lies in their sensitivity and specificity for analyzing various compounds. It is well-known that PNSs have traditionally strong activity on cardiovascular diseases, such as atherosclerosis, intracerebral hemorrhage, or brain injury. The recent studies showed that PNSs also responded to osteoporosis, cancers, diabetes, and drug toxicity. However, some other studies also showed that some PNSs injections and special PNS components might lead to some biological toxicity under certain dosages. Conclusion: This review may be used as a basis for further research in the field of quantitative and qualitative analyses, and is expected to provide updated and valuable insights into the potential medicinal applications of PNSs. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; ISCHEMIA-REPERFUSION INJURY ; TANDEM MASS-SPECTROMETRY ; MESENCHYMAL STEM-CELLS ; RG1 REDUCES TOXICITY ; BURK. FH CHEN ; GINSENOSIDE RG1 ; QUANTITATIVE-ANALYSIS ; IN-VITRO ; ISCHEMIA/REPERFUSION INJURY |
| 资助项目 | Shanghai Committee of Science and Technology[18401931400] ; Budget Program of Shanghai University of Traditional Chinese Medicine[2016YSN22] ; National Standardization Project of Traditional Chinese Medicine of China[ZYBZH-C-YN-58] ; Applied Basic Research Programs of Yunnan Province, China[2018FB141] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000465049300042 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290046]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Pu, Yiqiong; Li, Ning |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai 201203, Peoples R China 2.Key Lab Sustainable Utilizat Panax Notoginseng Re, Kunming 650500, Yunnan, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai Key Lab Compound Chinese Med, MOE Key Lab Standardizat Chinese Med, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201203, Peoples R China 5.KPC Pharmaceut Inc, Res Inst, Kunming 650100, Yunnan, Peoples R China 6.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Congcong,Wang, Weiwei,Wang, Bing,et al. Analytical methods and biological activities of Panax notoginseng saponins: Recent trends[J]. JOURNAL OF ETHNOPHARMACOLOGY,2019,236:443-465. |
| APA | Xu, Congcong.,Wang, Weiwei.,Wang, Bing.,Zhang, Tong.,Cui, Xiuming.,...&Li, Ning.(2019).Analytical methods and biological activities of Panax notoginseng saponins: Recent trends.JOURNAL OF ETHNOPHARMACOLOGY,236,443-465. |
| MLA | Xu, Congcong,et al."Analytical methods and biological activities of Panax notoginseng saponins: Recent trends".JOURNAL OF ETHNOPHARMACOLOGY 236(2019):443-465. |
入库方式： OAI收割
来源：上海药物研究所
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