Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism
文献类型：期刊论文
| 作者 | Li Yuanmin1,4; Wang Linlin4; Dong Zhihui3; Wang Shiying2; Qi Lili2,4; Cho Kenka5; Zhang Zhou4; Li Na4; Hu Yurong1; Jiang Baohong4
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| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2019-04-01 |
| 卷号 | 57页码:255-261 |
| 关键词 | Salvianolic acid B Ginsenoside Rg1 Myocardialinfarction Myocardial fibrosis Cardiac remodeling |
| ISSN号 | 0944-7113 |
| DOI | 10.1016/j.phymed.2018.12.040 |
| 通讯作者 | Hu Yurong(huyr@zzu.edu.cn) ; Jiang Baohong(jiangbh@simm.ac.cn) |
| 英文摘要 | Background: Following myocardial infarction (MI), a series of structural and functional changes evolves in the myocardium, collectively defined as cardiac remodeling. Purpose: The aim of present study was to investigate the cardioprotection of salvianolicacid B (SalB) and ginsenoside Rg1 (Rg1) combination against cardiac remodeling in a rat model at the subacute phase of MI and further elucidate the underlying mechanism. Methods: Rat heart was exposed via a left thoracotomy at the fourth intercostal space and MI was induced by a ligature below the left descending coronary artery. Hemodynamic assay was conducted using a Mikro-tipped SPR-320 catheter which was inserted through the right carotid artery into left ventricle. Myocardial infarct size was detected using 3,5-triphenyltetrazolium chloride (TTC) staining. Haematoxylin and eosin (HE) stain and picric sirius red stain were conducted for histopathological detection. Immunohistochemistry was used to detect the expression of alpha-smooth muscle actin (alpha-SMA) and gelatin zymography was used to evaluate the activities of matrix metalloproteinase-9 (MMP-9). Results: Comparing with MI rats, 30 mg/kg SalB-Rg1 improved cardiac function verified by maximum rate of pressure development for contraction (+dp/dt(max), p < 0.01) and maximum rate of pressure development for relaxation (-dp/dt(max), p < 0.05); reduced myocardial infarct size (p < 0.05) verified by TTC staining, improved cardiac structure based on HE stain; decreased collagen volume fraction (p < 0.05) and collagen I/III ratio (p < 0.05) according picrosirius red staining. The underlying mechanism of SalB-Rg1 against cardiac remodeling was associated with its down-regulation on alpha-SMA expression according immunohistochemistry (p < 0.01) and inhibition on MMP-9 activity based on in-gel zymography (p < 0.05). Conclusion: All above study indicated the potential therapeutic effects of SalB-Rg1 on heart. |
| WOS关键词 | CARDIAC FIBROSIS ; HEART-FAILURE ; COLLAGEN ; RECRUITMENT ; FIBROBLASTS |
| 资助项目 | National Natural Science Foundation of China[81573646] ; Shanghai Science and Technology Development Foundation[16401901800] ; Bureau of Science and Technology for Development Chinese Academy of Sciences[ZSTH-011] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000465081700027 |
| 出版者 | ELSEVIER GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290119]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu Yurong; Jiang Baohong |
| 作者单位 | 1.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China 2.Agr Univ Hebei Prov, Baoding 071001, Hebei, Peoples R China 3.Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo 6660162, Japan |
| 推荐引用方式 GB/T 7714 | Li Yuanmin,Wang Linlin,Dong Zhihui,et al. Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism[J]. PHYTOMEDICINE,2019,57:255-261. |
| APA | Li Yuanmin.,Wang Linlin.,Dong Zhihui.,Wang Shiying.,Qi Lili.,...&Jiang Baohong.(2019).Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism.PHYTOMEDICINE,57,255-261. |
| MLA | Li Yuanmin,et al."Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism".PHYTOMEDICINE 57(2019):255-261. |
入库方式： OAI收割
来源：上海药物研究所
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