One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
文献类型：期刊论文
| 作者 | Chen, Liang1,2,3; Zhu, Huajian1,2,3; Wang, Jiang2,3 ; Liu, Hong1,2,3
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 24期号:5页码:13 |
| 关键词 | NBS nitrogen-containing heterocycle water one-pot |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules24050893 |
| 通讯作者 | Wang, Jiang(jwang@simm.ac.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of alpha-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions. |
| WOS关键词 | N-BROMOSUCCINIMIDE ; ORGANIC-SYNTHESIS ; IMIDAZOPYRIDINES ; ZOLIMIDINE ; CHEMISTRY ; OXIDATION ; SULFONES ; GREEN ; ARYL ; BOND |
| 资助项目 | National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21672231] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000462662900069 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290137]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Jiang; Liu, Hong |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Liang,Zhu, Huajian,Wang, Jiang,et al. One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water[J]. MOLECULES,2019,24(5):13. |
| APA | Chen, Liang,Zhu, Huajian,Wang, Jiang,&Liu, Hong.(2019).One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water.MOLECULES,24(5),13. |
| MLA | Chen, Liang,et al."One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water".MOLECULES 24.5(2019):13. |
入库方式： OAI收割
来源：上海药物研究所
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