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Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity

文献类型：期刊论文

作者Qiao, Jin1; Jia, Xiuwen1; Li, Pinyi1; Liu, Xiaoyan1; Zhao, Jingwei1; Zhou, Yu2,3,4; Wang, Jiang2,3,4; Liu, Hong2,3,4; Zhao, Fei1
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2019-03-15
卷号361期号:6页码:1419-1440
关键词Alkynes Amines Cascade reaction Compound library Gold Scaffold diversity
ISSN号1615-4150
DOI10.1002/adsc.201801494
通讯作者Liu, Hong(hliu@simm.ac.cn) ; Zhao, Fei(zhaofei@cdu.edu.cn)
英文摘要1,3-unsubstituted 2-(1H-indol-2-yl)ethanamines were employed for the first time to react with alkynoic acids (AAs) to achieve gold-catalyzed highly selective cascade reactions to furnish novel indole-fused skeletons. Furthermore, with this powerful gold catalytic system, a library of indole/pyrrole/thiophene/benzene/naphthalene/pyridine-based nitrogen-containing heterocyclic compounds (NCHCs) with scaffold diversity and molecular complexity was constructed rapidly using various amine nucleophiles (ANs) and diverse AAs as the building blocks. This general protocol features excellent selectivity, extraordinarily broad substrate scope, readily available inputs, good to high yields, high bond-forming efficiency, and step economy, thus providing a facile and efficient access to a variety of valuable nitrogen-containing heterocycles.
WOS关键词FRIEDEL-CRAFTS REACTION ; GOLD(I)-CATALYZED INTRAMOLECULAR HYDROAMINATION ; SEQUENTIAL ALKYNE ACTIVATION ; SELECTIVE PDE5 INHIBITOR ; NATURAL-PRODUCTS ; DIASTEREOSELECTIVE SYNTHESIS ; CASCADE CYCLIZATION ; INDOLE ALKALOIDS ; STEREOSELECTIVE-SYNTHESIS ; PRIVILEGED STRUCTURES
资助项目National Natural Science Foundation of China[21602022] ; National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; 1000 Talents Program of Sichuan Province ; Chengdu Talents Program of Sichuan Province ; Technology Planning Program of Sichuan Province[2018JY0345] ; Chengdu University New Faculty Start-up Funding[2081915037]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000462674700030
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/290178]  
专题新药研究国家重点实验室
通讯作者Liu, Hong; Zhao, Fei
作者单位1.Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, 168 Hua Guan Rd, Chengdu 610052, Sichuan, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Qiao, Jin,Jia, Xiuwen,Li, Pinyi,et al. Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity[J]. ADVANCED SYNTHESIS & CATALYSIS,2019,361(6):1419-1440.
APA Qiao, Jin.,Jia, Xiuwen.,Li, Pinyi.,Liu, Xiaoyan.,Zhao, Jingwei.,...&Zhao, Fei.(2019).Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity.ADVANCED SYNTHESIS & CATALYSIS,361(6),1419-1440.
MLA Qiao, Jin,et al."Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity".ADVANCED SYNTHESIS & CATALYSIS 361.6(2019):1419-1440.

入库方式： OAI收割

来源：上海药物研究所

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