Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections
文献类型：期刊论文
| 作者 | Li, Xue2; Semiramoth, Nicolas1; Hall, Shaun3; Tafani, Virginie4; Josse, Jerome4; Laurent, Frederic4; Salzano, Giuseppina2; Foulkes, Daniel2; Brodin, Priscille5; Majlessi, Laleh6 |
| 刊名 | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 36期号:3页码:9 |
| ISSN号 | 0934-0866 |
| 关键词 | antibiotic coencapsulation macrophage metal-organic frameworks nanoparticles molecular simulations |
| DOI | 10.1002/ppsc.201800360 |
| 通讯作者 | Li, Xue() ; Gref, Ruxandra(ruxandra.gref@u-psud.fr) |
| 英文摘要 | Combinatorial drug therapies emerge among the most promising strategies to treat complex pathologies such as cancer and severe infections. Biocompatible nanoparticles of mesoporous iron carboxylate metal-organic framework (nanoMOFs) are used here to address the challenging aspects related to the coincorporation of two antibiotics. Amoxicillin and potassium clavulanate, a typical example of drugs used in tandem, are efficiently coincorporated with payloads up to 36 wt%. Due to the occurrence of two distinct pore sizes/apertures within the MOF architecture, each drug is able to infiltrate the porous framework and localize within separate compartments. Molecular simulations predict drug loadings and locations consistent with experimental findings. Drug loaded nanoMOFs that are internalized by Staphylococcus aureus infected macrophages are able to colocalize with the pathogen, which in turn leads to an alleviation of bacterial infection. The data also reveal potential antibacterial properties of nanoMOFs alone as well as their ability to deliver a high payload of drugs to fight intracellular bacteria. These results pave the way toward the design of engineered "all-in-one" nanocarriers in which both the loaded drugs and their carrier play a role in fighting intracellular infections. |
| WOS关键词 | ORGANIC FRAMEWORK NANOPARTICLES ; HYDROPHILIC ANTICANCER DRUG ; METAL ; DELIVERY ; MIL-100(FE) ; ADSORPTION ; CHALLENGES ; PLATFORM ; SYSTEMS |
| 资助项目 | European Union through Cyclon Hit project (People-2013-ITN)[608407] ; French National Research Agency (ANR) as part of the Investissements d'Avenir program (Labex NanoSaclay)[ANR-10-LABX-0035] ; French ANR project AntiTBnano[ANR-14-CE08-0017] ; French ANR project Virmil[ANR-2010-RMNP-004-01] ; Institut Universitaire de France |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000461878400007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290186]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Xue; Gref, Ruxandra |
| 作者单位 | 1.Univ Paris Sud, Univ Paris Saclay, UMR CNRS 8612, Inst Galien, F-92290 Chatenay Malabry, France 2.Univ Paris Sud, Univ Paris Saclay, UMR CNRS 8214, Inst Sci Mol Orsay, F-91405 Orsay, France 3.Univ Montpellier, Inst Charles Gerhardt, UMR CNRS 5253, Ecole Natl Super Chim Montpellier, F-34095 Montpellier 5, France 4.Hosp Civils Lyon, INSERM U1111, Ctr Int Rech Infectiol, F-69004 Lyon, France 5.Univ Lille, CHU Lille, INSERM U1019, CNRS UMR 8204,Inst Pasteur Lille, F-59000 Lille, France 6.Inst Pasteur, CNRS UMR 3525, Unit Integrated Mycobacterial Pathogen, F-75015 Paris, France 7.PSL Res Univ, Ecole Super Phys & Chim Ind Paris, Ecole Normale Super Paris, FRE 2000,Inst Mat Poreux Paris, F-75005 Paris, France 8.Univ Paris Sud, EA4043 Ecosyst Microbien Digest & Sante, F-92290 Chatenay Malabry, France 9.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xue,Semiramoth, Nicolas,Hall, Shaun,et al. Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2019,36(3):9. |
| APA | Li, Xue.,Semiramoth, Nicolas.,Hall, Shaun.,Tafani, Virginie.,Josse, Jerome.,...&Gref, Ruxandra.(2019).Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,36(3),9. |
| MLA | Li, Xue,et al."Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 36.3(2019):9. |
入库方式： OAI收割
来源：上海药物研究所
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