Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava
文献类型：期刊论文
| 作者 | Wu, Qihao1,2,3; Ye, Fei2; Li, Xiao-Lu4; Liang, Lin-Fu; Sun, Jiadong5; Sun, Han4; Guo, Yue-Wei1,2,3 ; Wang, Hong1,3
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2019-03-15 |
| 卷号 | 84期号:6页码:3083-3092 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.8b02912 |
| 通讯作者 | Guo, Yue-Wei(ywguo@simm.ac.cn) ; Wang, Hong(hongw@zjut.edu.cn) |
| 英文摘要 | A detailed chemical investigation of the Chinese soft coral Lemnalia flava yielded four new nardosinane-type sesquiterpenoids (1-4), one new neolemnane-type sesquiterpenoid (5), and one new sesquiterpenoid with an uncommon 6/9 fused bicyclic skeleton (6), together with two known related compounds (7 and 8). The structures and absolute configurations of 1-8 were determined on the basis of extensive spectroscopic data analyses, X-ray diffraction analysis, chemical reactions, and computer-assisted structural elucidation including C-13 NMR data calculation, residual dipolar coupling based NMR analysis, and time-dependent density functional theoryelectronic circular dichroism calculation. Plausible biogenetic pathways of two uncommon sesquiterpenoids (4 and 6) were proposed. |
| WOS关键词 | NARDOSINANE-TYPE SESQUITERPENOIDS ; STRUCTURE ELUCIDATION ; ABSOLUTE-CONFIGURATION ; DITERPENE GLYCOSIDES ; CIRCULAR-DICHROISM ; STRUCTURE REVISION ; SPECTRA |
| 资助项目 | National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; National Natural Science Foundation of China (NSFC)[81520108028] ; National Natural Science Foundation of China (NSFC)[21672230] ; National Natural Science Foundation of China (NSFC)[81773628] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000461844000006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290193]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei; Wang, Hong |
| 作者单位 | 1.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China 4.Leibniz Forschungsinst Mol Pharmakol FMP, Robert Rossle Str 10, D-13125 Berlin, Germany 5.NIDDK, Lab Bioorgan Chem, NIH, Bethesda, MD 20892 USA |
| 推荐引用方式 GB/T 7714 | Wu, Qihao,Ye, Fei,Li, Xiao-Lu,et al. Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(6):3083-3092. |
| APA | Wu, Qihao.,Ye, Fei.,Li, Xiao-Lu.,Liang, Lin-Fu.,Sun, Jiadong.,...&Wang, Hong.(2019).Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava.JOURNAL OF ORGANIC CHEMISTRY,84(6),3083-3092. |
| MLA | Wu, Qihao,et al."Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava".JOURNAL OF ORGANIC CHEMISTRY 84.6(2019):3083-3092. |
入库方式： OAI收割
来源：上海药物研究所
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