Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature
文献类型：期刊论文
| 作者 | Bacalini, Maria Giulia2; Franceschi, Claudio2,3,4; Gentilini, Davide5; Ravaioli, Francesco3; Zhou, Xiaoyuan6,7,8; Remondini, Daniel9,10; Pirazzini, Chiara2; Giuliani, Cristina11,12; Marasco, Elena4; Gensous, Noemie3 |
| 刊名 | JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
 |
| 出版日期 | 2019 |
| 卷号 | 74期号:1页码:1-8 |
| 关键词 | DNA methylation Epigenetic clock Epithelialmesenchymal transition |
| ISSN号 | 1079-5006 |
| DOI | 10.1093/gerona/gly048 |
| 通讯作者 | Franceschi, Claudio(claudio.franceschi@unibo.it) |
| 英文摘要 | The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, we characterized the epigenetic profile of liver biopsies collected from 45 healthy liver donors ranging from 13 to 90 years old using the Infinium HumanMethylation450 BeadChip. The analysis indicates that a large remodeling in DNA methylation patterns occurs, with 8,823 age-associated differentially methylated CpG probes. Notably, these age-associated changes tended to level off after the age of 60, as confirmed by Horvaths clock. Using stringent selection criteria, we further identified a DNA methylation signature of aging liver including 75 genomic regions. We demonstrated that this signature is specific for liver compared to other tissues and that it is able to detect biological age-acceleration effects associated with obesity. Finally, we combined DNA methylation measurements with available expression data. Although the intersection between the two omic characterizations was low, both approaches suggested a previously unappreciated role of epithelialmesenchymal transition and Wnt-signaling pathways in the aging of human liver. |
| WOS关键词 | EPITHELIAL-MESENCHYMAL TRANSITION ; DNA METHYLATION ; GENE-EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; CELL-PROLIFERATION ; TUMOR-SUPPRESSOR ; AGE ; HYPERMETHYLATION ; CANCER ; FETAL |
| 资助项目 | Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) ; Horizon 2020 Framework Programme[634821] ; JPco-fuND ; H2020 Marie Sklodowska-Curie Actions[675003] ; [602757] |
| WOS研究方向 | Geriatrics & Gerontology |
| 语种 | 英语 |
| WOS记录号 | WOS:000462190200001 |
| 出版者 | OXFORD UNIV PRESS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290210]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Franceschi, Claudio |
| 作者单位 | 1.Ist Auxol Italiano IRCCS, Milan, Italy 2.IRCCS Ist Sci Neurol Bologna, Bologna, Italy 3.Alma Mater Studiorum, DIMES Dept Expt Diagnost & Specialty Med, Via San Giacomo 12, I-40126 Bologna, Italy 4.Alma Mater Studiorum, CIG, Interdept Ctr L Galvani, Bologna, Italy 5.Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy 6.Shanghai Inst Biol Sci, Grp Clin Genom Networks, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China 7.Univ Chinese Acad Sci, Beijing, Peoples R China 8.Univ San Francisco, Dept Neurol, San Francisco, CA 94117 USA 9.Alma Mater Studiorum, Dept Phys & Astron DIFA, Bologna, Italy 10.Alma Mater Studiorum, INFN Sez Bologna, Bologna, Italy |
| 推荐引用方式 GB/T 7714 | Bacalini, Maria Giulia,Franceschi, Claudio,Gentilini, Davide,et al. Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2019,74(1):1-8. |
| APA | Bacalini, Maria Giulia.,Franceschi, Claudio.,Gentilini, Davide.,Ravaioli, Francesco.,Zhou, Xiaoyuan.,...&Garagnani, Paolo.(2019).Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,74(1),1-8. |
| MLA | Bacalini, Maria Giulia,et al."Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 74.1(2019):1-8. |
入库方式： OAI收割
来源：上海药物研究所
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