Design and synthesis of novel dual-cyclic RGD peptides for alpha(v)beta(3) integrin targeting
文献类型：期刊论文
| 作者 | Liu, Junjie2,3; Cheng, Xiaozhong1; Tian, Xiaobo2,3; Guan, Dongliang3,4; Ao, Jiwei3; Wu, Zhimeng1; Huang, Wei3,4; Le, Zhiping2 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2019-04-01 |
| 卷号 | 29期号:7页码:896-900 |
| 关键词 | alpha(v)beta(3) integrin RGD cyclic peptide Tumor-targeting Cyclo(RGDfK) Adhesion inhibition |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2019.01.043 |
| 通讯作者 | Wu, Zhimeng(zwu@jiangnan.edu.cn) ; Huang, Wei(huangwei@simm.ac.cn) ; Le, Zhiping(zple@ncu.edu.cn) |
| 英文摘要 | The specific binding of RGD cyclic peptide with integrin alpha(v)beta(3 )attracts great research interest for tumor-targeting drug delivery. Herein, we designed and synthesized a series of dual-ring RGD-peptide derivatives as a drug carrier for alpha(v)beta(3) targeting. Three novel peptides showed excellent cell adhesion inhibition effect, in which, P3 exhibited 7-fold enhancement in IC50 compared with cyclo(RGDfK). Drug-loaded cytotoxicity experiment and imaging experiment indicated that such dual-cyclic RGD peptides have good tumor targeting effects. This work provides a new strategy for the design of novel RGD peptides. |
| WOS关键词 | STABILITY ; POTENT |
| 资助项目 | National Natural Science Foundation of China (NNSFC)[21572244] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000459853300007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290245]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Zhimeng; Huang, Wei; Le, Zhiping |
| 作者单位 | 1.Jiangnan Univ, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Sch Biotechnol, Wuxi 214122, Peoples R China 2.Nanchang Univ, Dept Chem, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Receptor Res, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Junjie,Cheng, Xiaozhong,Tian, Xiaobo,et al. Design and synthesis of novel dual-cyclic RGD peptides for alpha(v)beta(3) integrin targeting[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2019,29(7):896-900. |
| APA | Liu, Junjie.,Cheng, Xiaozhong.,Tian, Xiaobo.,Guan, Dongliang.,Ao, Jiwei.,...&Le, Zhiping.(2019).Design and synthesis of novel dual-cyclic RGD peptides for alpha(v)beta(3) integrin targeting.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,29(7),896-900. |
| MLA | Liu, Junjie,et al."Design and synthesis of novel dual-cyclic RGD peptides for alpha(v)beta(3) integrin targeting".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 29.7(2019):896-900. |
入库方式： OAI收割
来源：上海药物研究所
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