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Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance

文献类型：期刊论文

作者Pan, Rui-Yuan2,3,4; Ma, Jun4; Kong, Xiang-Xi4; Wang, Xiao-Feng5; Li, Shuo-Shuo2,3,4; Qi, Xiao-Long2,3,4; Yan, Yu-Han6; Cheng, Jinbo4; Liu, Qingsong7; Jin, Wanzhu1
刊名SCIENCE ADVANCES
出版日期2019-02-01
卷号5期号:2页码:15
ISSN号2375-2548
DOI10.1126/sciadv.aau6328
通讯作者Yuan, Zengqiang(zyuan620@yahoo.com)
英文摘要The accumulation of aggregated amyloid-beta (A beta) in the brain is the first critical step in the pathogenesis of Alzheimer's disease (AD), which also includes synaptic impairment, neuroinflammation, neuronal loss, and eventual cognitive defects. Emerging evidence suggests that impairment of A beta phagocytosis and clearance is a common phenotype in late-onset AD. Rutin (quercetin-3-rutinoside) has long been investigated as a natural flavonoid with different biological functions in some pathological circumstances. Sodium rutin (NaR), could promote A beta clearance by increasing microglial by increasing the expression levels of phagocytosis-related receptors in microglia. Moreover, NaR promotes a metabolic switch from anaerobic glycolysis to mitochondrial OXPHOS (oxidative phosphorylation), which could provide microglia with sufficient energy (ATP) for A beta clearance. Thus, NaR administration could attenuate neuroinflammation and enhance mitochondrial OXPHOS and microglia-mediated A beta clearance, ameliorating synaptic plasticity impairment and eventually reversing spatial learning and memory deficits. Our findings suggest that NaR is a potential therapeutic agent for AD.
WOS关键词TRANSGENIC MICE ; MOUSE MODEL ; HYPOTHESIS ; PHAGOCYTOSIS ; MECHANISMS
资助项目National Nature Science Foundation of China[81630026] ; National Nature Science Foundation of China[81400987] ; Beijing Nature Science Foundation[7161009] ; Beijing Innovation Program[16CXZ028]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000460145700029
出版者AMER ASSOC ADVANCEMENT SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/290262]  
专题中国科学院上海药物研究所
通讯作者Yuan, Zengqiang
作者单位1.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
4.Beijing Inst Basic Med Sci, Brain Sci Ctr, Beijing 100850, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China
6.Dalian Med Univ, Dept Physiol, Dalian 116044, Peoples R China
7.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
8.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714		 Pan, Rui-Yuan,Ma, Jun,Kong, Xiang-Xi,et al. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance[J]. SCIENCE ADVANCES,2019,5(2):15.
APA Pan, Rui-Yuan.,Ma, Jun.,Kong, Xiang-Xi.,Wang, Xiao-Feng.,Li, Shuo-Shuo.,...&Yuan, Zengqiang.(2019).Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance.SCIENCE ADVANCES,5(2),15.
MLA Pan, Rui-Yuan,et al."Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance".SCIENCE ADVANCES 5.2(2019):15.

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来源：上海药物研究所

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