Cell Permeable NBD Peptide-Modified Liposomes by Hyaluronic Acid Coating for the Synergistic Targeted Therapy of Metastatic Inflammatory Breast Cancer
文献类型：期刊论文
| 作者 | Sun, Yuqing2; Li, Xuqian2; Zhang, Lili1; Liu, Xiao2; Jiang, Baohong3; Long, Zhiguo4; Jiang, Yanyan2 |
| 刊名 | MOLECULAR PHARMACEUTICS
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 16期号:3页码:1140-1155 |
| 关键词 | TAT-NBD peptide curcumin celecoxib anti-inflammation antimetastasis |
| ISSN号 | 1543-8384 |
| DOI | 10.1021/acs.molpharmaceut.8b01123 |
| 通讯作者 | Jiang, Yanyan(yanyanjiang@fudan.edu.cn) |
| 英文摘要 | Chronic inflammation is closely related to the development, deterioration, and metastasis of tumors. Recently, many studies have shown that down-regulating the expression of inflammation by blocking nuclear factor-kappa B (NF-kappa B) and signal transducer and activator of transcription 3 (STAT3) pathways could significantly inhibit tumor growth and metastasis. The combined application of curcumin (CUR) and celecoxib (CXB) has been proven to exert a synergistic antitumor effect via inhibiting the activation of NF-kappa B and STAT3. TAT-NBD (TN) peptide, a fusion peptide of NF-kappa B essential modulator (NEMO)-binding domain peptide (NBD) and cell-penetrating peptide (TAT), can selectively block NF-kappa B activating pathway resulting in tumor growth inhibition. In the present study, a novel TN-modified liposome coloading both CXB and CUR (TN-CCLP) at a synergistic ratio was first constructed with the property of synchronous release, then hyaluronic acid (HA) as CD44 targeting moiety was coated on the surface of the cationic liposome via electrostatic interaction to prepare the anionic HA/TN-CCLP. In vitro results of cytotoxicity, macrophage migration inhibition, and anti-inflammation efficacy revealed that TN-CCLP and HA/TN-CCLP were significantly superior to TN-LP and CCLP, while TN-CCLP exhibited better effects than HA/TN-CCLP due to higher cellular uptake ability. Different from in vitro data, after systematically treating 4T1 breast tumor-bearing mice, HA/TN-CCLP exerted the most striking effects on anti-inflammation, inhibition of macrophage recruitment, and antitumor because of the longest circulation time and maximum tumor accumulation. In particular, HA/TN-CCLP could availably block the lung metastasis of breast cancer. Taken together, the novel CD44 targeted TN-CCLP exhibited the potential for inhibiting tumor development and metastasis through improving inflammatory infiltration of tumor tissue. |
| WOS关键词 | NF-KAPPA-B ; CELECOXIB ; CURCUMIN ; DRUG ; INHIBITOR ; DELIVERY ; STAT3 ; NANOPARTICLES ; NANOCARRIERS ; MACROPHAGES |
| 资助项目 | National Natural Science Foundation of China[81371673] ; Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education, China |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000460600400020 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290267]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jiang, Yanyan |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Fudan Univ, Key Lab Smart Drug Delivery, Sch Pharm, Minist Educ,Dept Pharmaceut, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Materia Med, Shanghai 201203, Peoples R China 4.Fudan Univ, Shanghai Pudong Hosp, Dept Hematol, Shanghai 201399, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yuqing,Li, Xuqian,Zhang, Lili,et al. Cell Permeable NBD Peptide-Modified Liposomes by Hyaluronic Acid Coating for the Synergistic Targeted Therapy of Metastatic Inflammatory Breast Cancer[J]. MOLECULAR PHARMACEUTICS,2019,16(3):1140-1155. |
| APA | Sun, Yuqing.,Li, Xuqian.,Zhang, Lili.,Liu, Xiao.,Jiang, Baohong.,...&Jiang, Yanyan.(2019).Cell Permeable NBD Peptide-Modified Liposomes by Hyaluronic Acid Coating for the Synergistic Targeted Therapy of Metastatic Inflammatory Breast Cancer.MOLECULAR PHARMACEUTICS,16(3),1140-1155. |
| MLA | Sun, Yuqing,et al."Cell Permeable NBD Peptide-Modified Liposomes by Hyaluronic Acid Coating for the Synergistic Targeted Therapy of Metastatic Inflammatory Breast Cancer".MOLECULAR PHARMACEUTICS 16.3(2019):1140-1155. |
入库方式： OAI收割
来源：上海药物研究所
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