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Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis

文献类型：期刊论文

作者Yang, Min1,3; Li, Xiao-Lu2; Wang, Jian-Rong3; Lei, Xinxiang4; Tang, Wei3; Li, Xu-Wen1,3; Sun, Han2; Guo, Yue-Wei1,3,5
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-03-01
卷号84期号:5页码:2568-2576
ISSN号0022-3263
DOI10.1021/acs.joc.8b03020
通讯作者Li, Xu-Wen(xwli@simm.ac.cn) ; Sun, Han(hsun@fmp-berlin.de) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要A novel diterpenoid, sarcomililate A (1), possessing a previously undescribed tricyclo[11.3.0.0(2,16)]hexadecane scaffold, along with two new cembranoids, sarcomililatols A and B (2 and 3), and two known related diterpenoids (4 and 5), was isolated from the Hainan soft coral Sarcophyton mililatensis. The complete chemical structure including absolute configuration (AC) of 1 was unambiguously determined by a combination of residual dipolar coupling (RDC)-based NMR analysis, TDDFT-ECD (ECD = electronic circular dichroism) calculation, and Snatzkes method. The AC of 1 was further confirmed by a comparison with 2, whose AC was determined by anomalous X-ray diffraction. A plausible biogenetic relationship of 1-3 was further proposed. All the reported compounds exhibited interesting inhibitory effects on the ConA-induced T lymphocytes and/or lipopolysaccharide (LPS)-induced B lymphocytes proliferation.
WOS关键词ABSOLUTE-CONFIGURATION ; STRUCTURE ELUCIDATION ; CEMBRANOIDS ; DERIVATIVES ; VALIDATION ; COMPLEXES ; 1,2-DIOLS
资助项目National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; National Natural Science Foundation of China (NSFC)[81520108028] ; National Natural Science Foundation of China (NSFC)[21672230] ; National Natural Science Foundation of China (NSFC)[81603022] ; SKLDR/SIMM Project[SIMM1705ZZ-01] ; Sino-German Center for Research Promotion[GZ1289] ; Chinese Academy of Sciences[2016258] ; SA - SIBS Scholarship Program
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000460491600016
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/290314]  
专题新药研究国家重点实验室
通讯作者Li, Xu-Wen; Sun, Han; Guo, Yue-Wei
作者单位1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
2.Leibniz Forschungsinst Mol Pharmakol FMP, Robert Rossle Str 10, D-13125 Berlin, Germany
3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
5.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Min,Li, Xiao-Lu,Wang, Jian-Rong,et al. Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(5):2568-2576.
APA Yang, Min.,Li, Xiao-Lu.,Wang, Jian-Rong.,Lei, Xinxiang.,Tang, Wei.,...&Guo, Yue-Wei.(2019).Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis.JOURNAL OF ORGANIC CHEMISTRY,84(5),2568-2576.
MLA Yang, Min,et al."Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis".JOURNAL OF ORGANIC CHEMISTRY 84.5(2019):2568-2576.

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来源：上海药物研究所

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