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Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer

文献类型：期刊论文

作者Lang, Tianqun2,3,4; Dong, Xinyue2,3,5; Zheng, Zhong2,3,6; Liu, Yiran2,3,5; Wang, Guanru2,3,4; Yin, Qi2,3,4; Li, Yaping1,2,3,4
刊名SCIENCE BULLETIN
出版日期2019-01-30
卷号64期号:2页码:91-100
关键词Breast cancer Dual-sensitive micelle Metastasis Tumor-targeting
ISSN号2095-9273
DOI10.1016/j.scib.2018.12.025
通讯作者Yin, Qi(qyin@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Efficient tumor-targeting drug delivery systems are urgently needed for treating metastatic breast cancer. In this work, a docetaxel (DTX)-loaded micelle (pDM) as the tumor-microenvironment-responsive delivery platform is developed. The micelle is composed of a pH-sensitive amphiphilic copolymer, poly((1,4-butanediol)-diacrylate-beta-N, N-diisopropylethylenediamine)-polyethyleneimine (BD-PEI), and a matrix metalloproteinase (MMP)-responsive polymer, poly((1,4-butanediol)-diacrylate-beta-N, N-diisopropy lethylenediamine)-peptide-polyethylene glycol (PEG) (BD-peptide-PEG). The PEG block of BD-peptide-PEG will be split by MMPs at the tumor microenvironment, which leads to the change of the surface charge and particle size of the micelle to more positive and smaller one. Owing to this transformation and enhanced permeability and retention (EPR) effect, pDM delivers more DTX into tumor tissues and is internalized more efficiently by tumor cells than the non-MMP-sensitive micelles in the 4T1 tumor-bearing mice model. In addition, DTX is released in acidic endo/lysosomes due to the dissociation of the micelle, triggered by the protonation of the hydrophobic block of BD-PEI. As a result, the DTX-loaded micelle inhibits primary tumor growth and pulmonary metastasis effectively. Thus, this pH/MMP-dual-sensitive drug delivery system, which simultaneously attains three keypoints: prolonged circulation time, directional and efficient uptake into tumor cells, and speedy intracellular drug release, is a promising strategy for metastatic breast cancer therapy. (C) 2018 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
WOS关键词DRUG-DELIVERY ; MATRIX-METALLOPROTEINASES ; ENHANCED PERMEABILITY ; PHOTOTHERMAL THERAPY ; NANOPARTICLES ; CHEMOTHERAPY ; ANTICANCER ; EFFICACY ; SYSTEMS
资助项目National Natural Science Foundation of China[81871471] ; National Natural Science Foundation of China[81630052] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81521005] ; Key Scientific Research Program of Chinese Academy of Sciences[QYZDJSSW-SMC020] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2015226]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000460872100005
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/290389]  
专题新药研究国家重点实验室
通讯作者Yin, Qi; Li, Yaping
作者单位1.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
5.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China
6.Jilin Univ, Coll Life Sci, Changchun 130012, Jilin, Peoples R China
推荐引用方式
GB/T 7714		 Lang, Tianqun,Dong, Xinyue,Zheng, Zhong,et al. Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer[J]. SCIENCE BULLETIN,2019,64(2):91-100.
APA Lang, Tianqun.,Dong, Xinyue.,Zheng, Zhong.,Liu, Yiran.,Wang, Guanru.,...&Li, Yaping.(2019).Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer.SCIENCE BULLETIN,64(2),91-100.
MLA Lang, Tianqun,et al."Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer".SCIENCE BULLETIN 64.2(2019):91-100.

入库方式： OAI收割

来源：上海药物研究所

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