Study on the herb-herb interaction of Danqi Tongmai Tablet based on the pharmacokinetics of twelve notoginsenoides in acute myocardial ischemia and sham rats
文献类型：期刊论文
| 作者 | Zhi, Haijuan; Deng, Yanping; Yan, Bingpeng; Li, Zhenwei; Han, Sumei; Zhang, Yibei; Hou, Jinjun ; Wu, Wanying; Guo, Dean
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| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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| 出版日期 | 2019-03-20 |
| 卷号 | 166页码:52-65 |
| 关键词 | Danqi Tongmai tablet Herb-herb interaction Acute myocardial ischemic UHPLC-TQ/MS Pharmacokinetics |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2018.12.043 |
| 通讯作者 | Hou, Jinjun(jinjun_hou@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn) |
| 英文摘要 | Danqi Tongmai tablet (DQTT), an innovative TCM formula under clinical trials, is composed of salvianolic acids (SA) and panax notoginsenosides (PNE) for the treatment of coronary heart disease and angina pectoris. However, the in vivo herb-herb interaction of DQTT remains unclear. In the present research, a rapid, reliable and sensitive method for quantitative analysis of multi-notoginsenoside in rat plasma based on ultra high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-TQ/MS) was established and then applied to explore the herb-herb interaction mechanism of DQTT based on the pharmacokinetics in acute myocardial ischemia (AMI) and sham rats after oral administration of DQTT and PNE. Compared with sham rats after oral administration of PNE, the values of AUC(0-t) for Rf and Rb2 were significantly higher in DQTT group. Compared with AMI rats after oral PNE, AUC(0-t) for NR1, Rg1, Re, Rb1, Rd, Rg2, Rb2, NR2, Rh1, F1 and F2 were significantly increased after oral administration of DQTT. These results hinted that SA could improve the bioavailability of notoginsenosides in AMI rats, which provides scientific information for better understanding the herb-herb interaction mechanism and offers a reference for clinical administration of DQTT. Additionally, the presently developed methodology was simple, robust, accurate, precise, and would be useful for the pharmacokinetic studies for all kinds of notoginsenosides and other herbal saponins. (C) 2018 Elsevier B.V. All rights reserved. |
| WOS关键词 | DRUG INTERACTIONS ; DIABETIC-RATS ; PLASMA ; SAPONINS ; COMPONENTS ; MS/MS ; ACID ; MICE ; METABOLISM ; ABSORPTION |
| 资助项目 | National Natural Science Foundation of China[81530095] ; National Science and Technology Major Project[2017ZF001] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000460713700007 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290393]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hou, Jinjun; Wu, Wanying |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhi, Haijuan,Deng, Yanping,Yan, Bingpeng,et al. Study on the herb-herb interaction of Danqi Tongmai Tablet based on the pharmacokinetics of twelve notoginsenoides in acute myocardial ischemia and sham rats[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2019,166:52-65. |
| APA | Zhi, Haijuan.,Deng, Yanping.,Yan, Bingpeng.,Li, Zhenwei.,Han, Sumei.,...&Guo, Dean.(2019).Study on the herb-herb interaction of Danqi Tongmai Tablet based on the pharmacokinetics of twelve notoginsenoides in acute myocardial ischemia and sham rats.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,166,52-65. |
| MLA | Zhi, Haijuan,et al."Study on the herb-herb interaction of Danqi Tongmai Tablet based on the pharmacokinetics of twelve notoginsenoides in acute myocardial ischemia and sham rats".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 166(2019):52-65. |
入库方式： OAI收割
来源：上海药物研究所
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