Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins
文献类型：期刊论文
| 作者 | Ai, Lingsheng2; Wang, Weijin2; Wei, Jialiang2; Li, Qing2; Song, Song1,2; Jiao, Ning1,2 |
| 刊名 | SYNLETT
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 30期号:4页码:437-441 |
| 关键词 | halogenation alcohols dimethyl sulfoxide halohydrins oxidation |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/s-0037-1610385 |
| 通讯作者 | Song, Song(ssong@bjmu.edu.cn) ; Jiao, Ning(jiaoning@pku.edu.cn) |
| 英文摘要 | beta-Halohydrins bearing transformable halo- and hydroxyl groups, are easily converted into various valuable blocks in organic and pharmaceutical synthesis. A diastereoselective -halogenation of benzylic alcohols was achieved under simple and low-cost conditions, which provided a direct synthesis of -halohydrins. The simple reaction conditions, easily available reagents, high diastereoselectivities, and additional oxidant-free make this reaction very attractive and practical. |
| WOS关键词 | LAYERED DOUBLE HYDROXIDES ; C-H BONDS ; DIMETHYL-SULFOXIDE ; METHYL KETONES ; C(SP(3))-H FUNCTIONALIZATION ; CATALYTIC FUNCTIONALIZATION ; AROMATIC-COMPOUNDS ; MOLECULAR-OXYGEN ; FACILE SYNTHESIS ; BROMINATION |
| 资助项目 | National Basic Research Program of China (973 Program)[2015CB856600] ; National Natural Science Foundation of China[21602005] ; National Natural Science Foundation of China[21632001] ; National Natural Science Foundation of China[21772002] ; State Key Laboratory of Drug Research |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000459590400016 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290409]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Song, Song; Jiao, Ning |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ai, Lingsheng,Wang, Weijin,Wei, Jialiang,et al. Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins[J]. SYNLETT,2019,30(4):437-441. |
| APA | Ai, Lingsheng,Wang, Weijin,Wei, Jialiang,Li, Qing,Song, Song,&Jiao, Ning.(2019).Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins.SYNLETT,30(4),437-441. |
| MLA | Ai, Lingsheng,et al."Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins".SYNLETT 30.4(2019):437-441. |
入库方式： OAI收割
来源：上海药物研究所
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