Non-destructive 3D Microtomography of Cerebral Angioarchitecture Changes Following Ischemic Stroke in Rats Using Synchrotron Radiation
文献类型：期刊论文
| 作者 | Luo, Yonghong1; Yin, Xianzhen2; Shi, Shupeng1; Ren, Xiaolei3; Zhang, Haoran1; Wang, Zhuolu4,5; Cao, Yong6; Tang, Mimi7,8; Xiao, Bo1; Zhang, Mengqi1 |
| 刊名 | FRONTIERS IN NEUROANATOMY
 |
| 出版日期 | 2019-01-31 |
| 卷号 | 13页码:11 |
| 关键词 | ischemic stroke synchrotron radiation 3D vessel remodeling microtomography |
| ISSN号 | 1662-5129 |
| DOI | 10.3389/fnana.2019.00005 |
| 通讯作者 | Zhang, Mengqi(zhangmengqi8912@163.com) |
| 英文摘要 | A better understanding of functional changes in the cerebral microvasculature following ischemic injury is essential to elucidate the pathogenesis of stroke. Up to now, the simultaneous depiction and stereological analysis of 3D micro-architectural changes of brain vasculature with network disorders remains a technical challenge. We aimed to explore the three dimensional (3D) microstructural changes of microvasculature in the rat brain on 4, 6 hours, 3 and 18 days post-ischemia using synchrotron radiation micro-computed tomography (SR mu CT) with a per pixel size of 5.2 mu m. The plasticity of angioarchitecture was distinctly visualized. Quantitative assessments of time-related trends after focal ischemia, including number of branches, number of nodes, and frequency distribution of vessel diameter, reached a peak at 6 h and significantly decreased at 3 days and initiated to form cavities. The detected pathological changes were also proven by histological tests. We depicted a novel methodology for the 3D analysis of vascular repair in ischemic injury, both qualitatively and quantitatively. Cerebral angioarchitecture sustained 3D remodeling and modification during the healing process. The results might provide a deeper insight into the compensatory mechanisms of microvasculature after injury, suggesting that SR mu CT is able to provide a potential new platform for deepening imaging pathological changes in complicated angioarchitecture and evaluating potential therapeutic targets for stroke. |
| WOS关键词 | 3-DIMENSIONAL QUANTIFICATION ; ANGIOGENESIS ; TOMOGRAPHY ; VESSELS ; BRAIN ; MODEL |
| 资助项目 | National Natural Science Foundation of China[81501025] ; National Natural Science Foundation of China[81803233] ; Natural Science Foundation of Hunan Province[2016JJ3174] ; Natural Science Foundation of Hunan Province[2018JJ3834] ; Science Foundation of Xiangya Hospital for Young Scholar[2017Q01] ; Science Foundation of Xiangya Hospital for Young Scholar[2017Q13] |
| WOS研究方向 | Anatomy & Morphology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000458483300001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290587]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Mengqi |
| 作者单位 | 1.Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha, Hunan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai, Peoples R China 3.Cent S Univ, Xiangya Hosp 2, Dept Orthopaed, Changsha, Hunan, Peoples R China 4.Hunan Prov Maternal & Child Hlth Care Hosp, Dept Breast Surg, Changsha, Hunan, Peoples R China 5.Cent S Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Hunan, Peoples R China 6.Cent S Univ, Xiangya Hosp, Dept Spine Surg, Changsha, Hunan, Peoples R China 7.Cent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China 8.Cent S Univ, Inst Hosp Pharm, Xiangya Hosp, Changsha, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Yonghong,Yin, Xianzhen,Shi, Shupeng,et al. Non-destructive 3D Microtomography of Cerebral Angioarchitecture Changes Following Ischemic Stroke in Rats Using Synchrotron Radiation[J]. FRONTIERS IN NEUROANATOMY,2019,13:11. |
| APA | Luo, Yonghong.,Yin, Xianzhen.,Shi, Shupeng.,Ren, Xiaolei.,Zhang, Haoran.,...&Zhang, Mengqi.(2019).Non-destructive 3D Microtomography of Cerebral Angioarchitecture Changes Following Ischemic Stroke in Rats Using Synchrotron Radiation.FRONTIERS IN NEUROANATOMY,13,11. |
| MLA | Luo, Yonghong,et al."Non-destructive 3D Microtomography of Cerebral Angioarchitecture Changes Following Ischemic Stroke in Rats Using Synchrotron Radiation".FRONTIERS IN NEUROANATOMY 13(2019):11. |
入库方式： OAI收割
来源：上海药物研究所
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