gamma-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis
文献类型：期刊论文
| 作者 | Wang, Anqi1,2; Zhou, Fayang2; Li, Dan2; Lu, Jin-Jian2; Wang, Yitao2; Lin, Ligen2,3 |
| 刊名 | TOXICOLOGY AND APPLIED PHARMACOLOGY
 |
| 出版日期 | 2019-01-15 |
| 卷号 | 363页码:142-153 |
| 关键词 | gamma-Mangostin Fibrogenesis Sirtuin 3 HMGB1 Superoxide Liver fibrosis |
| ISSN号 | 0041-008X |
| DOI | 10.1016/j.taap.2018.11.011 |
| 通讯作者 | Lin, Ligen(ligenl@umac.mo) |
| 英文摘要 | The activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. In the current study, gamma-mangostin (gamma-man), one of the major xanthones from mangosteen (Garcinia mangostana), was found to alleviate fibrogenesis in human immortalized HSCs (LX-2 cells) and in liver from chronic carbon tetrachloride (CCl4) injured mice. gamma-Man suppressed the expression levels of collagen I and alpha-smooth muscle actin (alpha-SMA) in LX-2 cells in both dose and time dependent manners. Furthermore, gamma-man inhibited NAD(P)H oxidase activity through induction of sirtuin 3 (SIRT3), resulting in reduced intracellular oxidative stress in LX-2 cells. Moreover, gamma-man stimulated the expression of histone deacetylase 1, which in turn decreased the acetylation and cytoplasmic shuttling of high mobility group box 1 (HMGB1), to impair autocrine HMGB1-induced HSC activation. In CCl4-injured mice, gamma-man enhanced the expression of SIRT3 and decreased the expression of HMGB1, resulting in decreased accumulation of collagen I and alpha-SMA in liver. Consequently, gamma-man might be a potent candidate to treat oxidative stress induced liver fibrosis. |
| WOS关键词 | HEPATIC STELLATE CELLS ; CALORIE RESTRICTION ; OXIDATIVE INJURY ; GENE-EXPRESSION ; NADPH OXIDASES ; UP-REGULATION ; PROTEIN ; HMGB1 ; ACTIVATION ; XANTHONES |
| 资助项目 | Science and Technology Development Fund, Macao S.A.R[FDCT 102/2017/A] ; Research Fund of University of Macau[MYRG2017-00109-ICMS] ; State Key Laboratory of Drug Research[SIMM1803KF-16] |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000457068000015 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290590]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lin, Ligen |
| 作者单位 | 1.Guangdong Macau Tradit Chinese Med Technol Ind Pk, Hengqin New Area, Zhuhai 519031, Guangdong, Peoples R China 2.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macau, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Anqi,Zhou, Fayang,Li, Dan,et al. gamma-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2019,363:142-153. |
| APA | Wang, Anqi,Zhou, Fayang,Li, Dan,Lu, Jin-Jian,Wang, Yitao,&Lin, Ligen.(2019).gamma-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.TOXICOLOGY AND APPLIED PHARMACOLOGY,363,142-153. |
| MLA | Wang, Anqi,et al."gamma-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis".TOXICOLOGY AND APPLIED PHARMACOLOGY 363(2019):142-153. |
入库方式： OAI收割
来源：上海药物研究所
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