中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes

文献类型:期刊论文

作者Peng, Yingyuan1; Zhang, Xiaofei2; Qi, Xueyu2; He, Qian2; Zhang, Bin1; Hao, Jian1; Yang, Chunhao2
刊名EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-02-07
期号5页码:1170-1177
ISSN号1434-193X
关键词Addition gem-Difluorostyrene Phosphorus alpha-Fluorovinyl Phosphine oxide
DOI10.1002/ejoc.201801602
通讯作者Hao, Jian(jhao@shu.edu.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要A facile and efficient method for the synthesis of (E/Z)-alpha-fluorovinyl phosphorus compounds from gem-difluorostyrenes with diphenylphosphine oxide/dialkyl phosphate and DBU at room temperature was developed. A series of 1-fluorovinyl phosphine oxides/phosphonates were obtained with moderate to excellent yields in these reactions. Additionally, most isomers (E/Z type) of the target compounds could be easily separated and purified by column chromatography.
WOS关键词ALPHA-FLUORINATED PHOSPHONATES ; CRAFTS-TYPE CYCLIZATION ; CATALYZED HYDROPHOSPHORYLATION ; DIFLUOROALKENES ; ALKYNES ; FLUOROALKENYLATION ; ACTIVATION ; ALKYLATION ; EFFICIENT ; GENERATE
资助项目National Natural Science Foundation of China[2150208] ; National Natural Science Foundation of China[21672139] ; SKLDR/SIMM[SIMM1601ZZ-03]
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000458273900033
源URL[http://119.78.100.183/handle/2S10ELR8/290597]  
专题新药研究国家重点实验室
通讯作者Hao, Jian; Yang, Chunhao
作者单位1.Shanghai Univ, Dept Chem, Innovat Drug Res Ctr, Shangda Rd 99, Shanghai 200436, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Peng, Yingyuan,Zhang, Xiaofei,Qi, Xueyu,et al. Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2019(5):1170-1177.
APA Peng, Yingyuan.,Zhang, Xiaofei.,Qi, Xueyu.,He, Qian.,Zhang, Bin.,...&Yang, Chunhao.(2019).Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(5),1170-1177.
MLA Peng, Yingyuan,et al."Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .5(2019):1170-1177.

入库方式: OAI收割

来源:上海药物研究所

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