Highly selective C-H bond activation of N-arylbenzimidamide and divergent couplings with diazophosphonate compounds: a catalyst-controlled selective synthetic strategy for 3-phosphorylindoles and 4-phosphorylisoquinolines
文献类型：期刊论文
| 作者 | Yang, Qiaolan1,2,3; Wu, Chenglin2,3; Zhou, Jianhui2,3; He, Guoxue2,3; Liu, Hong2,3 ; Zhou, Yu2,3
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2019-02-07 |
| 卷号 | 6期号:3页码:393-398 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c8qo01148f |
| 通讯作者 | Liu, Hong(hliu@simm.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn) |
| 英文摘要 | A highly efficient synthetic strategy to construct 3-phosphorylindole and 4-phosphorylisoquinoline privileged scaffolds via selective C-H bond activations of N-phenylbenzimidamide and the subsequent divergent couplings with diazophosphonate compounds was achieved successfully by altering the Rh(III)/Ru(II) catalyst systems. This protocol features excellent chemoselectivity, wide substrate tolerance and mild reaction conditions, which might find wider application in the discovery of lead compounds in the future. |
| WOS关键词 | ARYL-PHOSPHO-INDOLE ; DIAZO-COMPOUNDS ; RH(III)-CATALYZED SYNTHESIS ; PROPARGYL ALCOHOLS ; PHOSPHORYLATION ; CYCLIZATION ; ANNULATION ; ACID ; ISOQUINOLINE ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040217] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000457450300015 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290603]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Zhou, Yu |
| 作者单位 | 1.Univ Sci & Technol China, Nano Sci & Technol Inst, 166 Ren Ai Rd, Suzhou 215123, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Qiaolan,Wu, Chenglin,Zhou, Jianhui,et al. Highly selective C-H bond activation of N-arylbenzimidamide and divergent couplings with diazophosphonate compounds: a catalyst-controlled selective synthetic strategy for 3-phosphorylindoles and 4-phosphorylisoquinolines[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(3):393-398. |
| APA | Yang, Qiaolan,Wu, Chenglin,Zhou, Jianhui,He, Guoxue,Liu, Hong,&Zhou, Yu.(2019).Highly selective C-H bond activation of N-arylbenzimidamide and divergent couplings with diazophosphonate compounds: a catalyst-controlled selective synthetic strategy for 3-phosphorylindoles and 4-phosphorylisoquinolines.ORGANIC CHEMISTRY FRONTIERS,6(3),393-398. |
| MLA | Yang, Qiaolan,et al."Highly selective C-H bond activation of N-arylbenzimidamide and divergent couplings with diazophosphonate compounds: a catalyst-controlled selective synthetic strategy for 3-phosphorylindoles and 4-phosphorylisoquinolines".ORGANIC CHEMISTRY FRONTIERS 6.3(2019):393-398. |
入库方式： OAI收割
来源：上海药物研究所
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