Palladium-Promoted DNA-Compatible Heck Reaction
文献类型：期刊论文
| 作者 | Wang, Xuan1,2; Sun, Hui1; Liu, Jiaxiang1; Zhong, Wenge2,3; Zhang, Mingqiang2; Zhou, Hu1 ; Dai, Dongcheng2; Lu, Xiaojie1
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 21期号:3页码:719-723 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.8b03926 |
| 通讯作者 | Dai, Dongcheng(ddai@amgen.com) ; Lu, Xiaojie(xjlu@simm.ac.cn) |
| 英文摘要 | Optimal conditions for palladium-promoted Heck reaction on DNA were developed with good to excellent conversions. Versatility with either DNA-conjugated styrene/acrylamide or aryl iodide and a broad substrate scope of the corresponding coupling partners were established. Furthermore, robustness of the Heck reaction conditions on single-strand DNA and feasibility for DNA-encoded library production were demonstrated. |
| WOS关键词 | ENCODED CHEMICAL LIBRARIES ; CATALYZED HECK ; COUPLING REACTIONS ; ACRYLIC-ACID ; SELECTION ; SYSTEM ; WATER |
| 资助项目 | Amgen |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000457947900030 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290607]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Dai, Dongcheng; Lu, Xiaojie |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China 2.Amgen Biopharmaceut R&D Shanghai Co Ltd, Amgen Asia R&D Ctr, 4560 Jinke Rd,Bldg 2,13th Floor, Shanghai 201210, Peoples R China 3.Regor Therapeut Inc, 576 Libing Rd,Bldg 2, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xuan,Sun, Hui,Liu, Jiaxiang,et al. Palladium-Promoted DNA-Compatible Heck Reaction[J]. ORGANIC LETTERS,2019,21(3):719-723. |
| APA | Wang, Xuan.,Sun, Hui.,Liu, Jiaxiang.,Zhong, Wenge.,Zhang, Mingqiang.,...&Lu, Xiaojie.(2019).Palladium-Promoted DNA-Compatible Heck Reaction.ORGANIC LETTERS,21(3),719-723. |
| MLA | Wang, Xuan,et al."Palladium-Promoted DNA-Compatible Heck Reaction".ORGANIC LETTERS 21.3(2019):719-723. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。