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A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of gamma-cyclodextrin metal-organic frameworks

文献类型：期刊论文

作者Xu, Jian1,2; Wu, Li1,3; Guo, Tao1; Zhang, Guoqing1,4; Wang, Caifen1; Li, Haiyan1; Li, Xue5; Singh, Vikramjeet1,5; Chen, Weidong4; Gref, Ruxandra5
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2019-02-10
卷号556页码:89-96
关键词Nanoclusters gamma-Cyclodextrin metal-organic frameworks Folic acid Drug loading Ship-in-a-Bottle
ISSN号0378-5173
DOI10.1016/j.ijpharm.2018.11.074
通讯作者Chen, Weidong(anzhongdong@126.com) ; Gref, Ruxandra(ruxandra.gref@u-psud.fr) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要Assembled between gamma-cyclodextrins (CD) and potassium ions, gamma-cyclodextrin metal-organic frameworks (CDMOF) create spatially extended and ordered cage-like structures. Herein, it was demonstrated that folic acid (FA), a model molecule, could be densely packed inside CD-MOF reaching 2:1 FA:CD molar ratio. This "Ship-ina-Bottle" strategy leads to a 1450 fold increase of the apparent solubility of FA. Moreover, the bioavailability of FA inside CD-MOF in rats was enhanced by a factor of 1.48 as compared to free FA. The unique mechanism of FA incorporation in the CD-MOF 3D network was also explored, which was different from the conventional CD inclusion complexation. Taylor dispersion investigations indicated that FA was incorporated on the basis of a two-component model, which was further supported by a set of complementary methods, including SEM, XRPD, BET, SR-FTIR, SAXS and molecular simulation. The hypothesized mechanism suggested that i) tiny FA nanoclusters formed inside the hydrophilic cavities and onto the surface of CD-MOF and ii) FA was included inside dual-CD units in CD-MOF. In a nutshell, this dual incorporation mechanism is an original approach to dramatically increase the drug apparent solubility and bioavailability, and could be a promising strategy for other poorly soluble drugs.
WOS关键词CARBON-DIOXIDE ; NANOPARTICLES ; ENCAPSULATION ; STABILITY ; DRUG ; IMPROVEMENT ; INCLUSION ; CURCUMIN ; CARRIERS ; MOF
资助项目National Science and Technology Major Projects for Major New Drugs Innovation and Development[2018ZX09721002-009] ; National Science and Technology Major Projects for Major New Drugs Innovation and Development[2017ZX09101001-005] ; National Key R&D Program of China[2016YFE0125100] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; National Nature Science Foundation of China[81773645] ; [AntiTBnano ANR-14-CE08-0017] ; [Antidote ANR-16-CE18-0018]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000455968700009
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/290728]  
专题中国科学院上海药物研究所
通讯作者Chen, Weidong; Gref, Ruxandra; Zhang, Jiwen
作者单位1.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201210, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China
4.Anhui Univ Chinese Med, Sch Pharmaceut Sci, Hefei 230012, Anhui, Peoples R China
5.Univ Paris Saclay, Inst Sci Mol Orsay, UMR CNRS 8214, F-91400 Orsay, France
推荐引用方式
GB/T 7714		 Xu, Jian,Wu, Li,Guo, Tao,et al. A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of gamma-cyclodextrin metal-organic frameworks[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2019,556:89-96.
APA Xu, Jian.,Wu, Li.,Guo, Tao.,Zhang, Guoqing.,Wang, Caifen.,...&Zhang, Jiwen.(2019).A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of gamma-cyclodextrin metal-organic frameworks.INTERNATIONAL JOURNAL OF PHARMACEUTICS,556,89-96.
MLA Xu, Jian,et al."A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of gamma-cyclodextrin metal-organic frameworks".INTERNATIONAL JOURNAL OF PHARMACEUTICS 556(2019):89-96.

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来源：上海药物研究所

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