Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp.
文献类型：期刊论文
| 作者 | Zhang, Quan1,2; Liang, Lin-Fu2,3; Miao, Ze-Hong2; Wu, Bin1; Guo, Yue-Wei2,4
|
| 刊名 | STEROIDS
 |
| 出版日期 | 2019 |
| 卷号 | 141页码:76-80 |
| 关键词 | Soft coral Lobophytum sp. Polyhydroxylated steroids Lobophysterols A-D Cytotoxicity |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2018.11.015 |
| 通讯作者 | Wu, Bin(wubin@zju.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Four new polyhydroxylated steroids lobophysterols A-D (1-4), together with two known related compounds sarcophytosterol (5) and klyflaccisteroid B (6), were isolated from the South China Sea soft coral Lobophytum sp. Their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature. In bioassay, compound 4 showed weak cytotoxicities against HT-29, SNU-398, and Capan-1 cells. |
| 资助项目 | National Key Research and Development Program of China[2018YFC0310903] ; National Natural Science Foundation of China[81520108028] ; National Natural Science Foundation of China[21672230] ; National Natural Science Foundation of China[41876194] ; National Natural Science Foundation of China[41506187] ; National Natural Science Foundation of China[81603022] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; SKLDR/SIMM Projects[SIMM 1705ZZ-01] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000456638900012 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290747]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wu, Bin; Guo, Yue-Wei |
| 作者单位 | 1.Zhejiang Univ, Ocean Coll, Hangzhou 310058, Zhejiang, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Quan,Liang, Lin-Fu,Miao, Ze-Hong,et al. Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp.[J]. STEROIDS,2019,141:76-80. |
| APA | Zhang, Quan,Liang, Lin-Fu,Miao, Ze-Hong,Wu, Bin,&Guo, Yue-Wei.(2019).Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp..STEROIDS,141,76-80. |
| MLA | Zhang, Quan,et al."Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp.".STEROIDS 141(2019):76-80. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。