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Remote Para-C-H Acetoxylation of Electron-Deficient Arenes

文献类型：期刊论文

作者Li, Minghong2; Shang, Ming2; Xu, Hui1; Wang, Xing1; Dai, Hui-Xiong1; Yu, Jin-Quan3
刊名ORGANIC LETTERS
出版日期2019-01-18
卷号21期号:2页码:540-544
ISSN号1523-7060
DOI10.1021/acs.orglett.8b03871
通讯作者Dai, Hui-Xiong(hxdai@simm.ac.cn) ; Yu, Jin-Quan(yu200@scripps.edu)
英文摘要One formidable challenge in sp(2) C-H activation is how to achieve high para selectivity on electron-deficient arenes because such site selectivity is disfavored by the electronic bias induced by the electron-withdrawing groups. The first highly selective para-C-H acetoxylation of various benzoic acids using a nitrile-based template was realized. Removal of the template leads to para-hydroxylated benzoic acids, which are versatile intermediates for a wide range of synthetically useful transformations.
WOS关键词ARYL HALIDES ; BORYLATION ; FUNCTIONALIZATION ; OLEFINATION ; SILYLATION ; AMINATION ; LIGAND
资助项目Shanghai Institute of Materia Medica ; Shanghai Institute of Organic Chemistry ; Chinese Academy of Sciences ; NSFC[21472211] ; NSFC[21502212] ; NSFC[21772211] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, the Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; NSF under the CCI Center for Selective C-H Functionalization[CHE-1205646]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000456633000041
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/290752]  
专题中国科学院上海药物研究所
通讯作者Dai, Hui-Xiong; Yu, Jin-Quan
作者单位1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, 555 Rd Chong Zhi,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 20032, Peoples R China
3.Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
推荐引用方式
GB/T 7714		 Li, Minghong,Shang, Ming,Xu, Hui,et al. Remote Para-C-H Acetoxylation of Electron-Deficient Arenes[J]. ORGANIC LETTERS,2019,21(2):540-544.
APA Li, Minghong,Shang, Ming,Xu, Hui,Wang, Xing,Dai, Hui-Xiong,&Yu, Jin-Quan.(2019).Remote Para-C-H Acetoxylation of Electron-Deficient Arenes.ORGANIC LETTERS,21(2),540-544.
MLA Li, Minghong,et al."Remote Para-C-H Acetoxylation of Electron-Deficient Arenes".ORGANIC LETTERS 21.2(2019):540-544.

入库方式： OAI收割

来源：上海药物研究所

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