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Machine Learning Methods in Precision Medicine Targeting Epigenetic Diseases

文献类型：期刊论文

作者Fan, Shijie1,3; Chen, Yu1,3; Luo, Cheng1,3; Meng, Fanwang2
刊名CURRENT PHARMACEUTICAL DESIGN
出版日期2018
卷号24期号:34页码:3998-4006
关键词Machine learning precision medicine epigenetics deep learning genome Human Genome Project (HGP)
ISSN号1381-6128
DOI10.2174/1381612824666181112114228
通讯作者Meng, Fanwang(mengf9@mcmaster.ca)
英文摘要Background: On a tide of big data, machine learning is coming to its day. Referring to huge amounts of epigenetic data coming from biological experiments and clinic, machine learning can help in detecting epigenetic features in genome, finding correlations between phenotypes and modifications in histone or genes, accelerating the screen of lead compounds targeting epigenetics diseases and many other aspects around the study on epigenetics, which consequently realizes the hope of precision medicine. Methods: In this minireview, we will focus on reviewing the fundamentals and applications of machine learning methods which are regularly used in epigenetics filed and explain their features. Their advantages and disadvantages will also be discussed. Results: Machine learning algorithms have accelerated studies in precision medicine targeting epigenetics diseases. Conclusion: In order to make full use of machine learning algorithms, one should get familiar with the pros and cons of them, which will benefit from big data by choosing the most suitable method(s).
WOS关键词DNA METHYLATION ; GENE-EXPRESSION ; GENOME ; CANCER ; CLASSIFICATION ; INHIBITORS ; PREDICTION ; DISCOVERY ; IDENTIFICATION ; INFORMATION
资助项目National Natural Science Foundation of China[81625022] ; National Natural Science Foundation of China[81430084]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000456318200003
出版者BENTHAM SCIENCE PUBL LTD
源URL[http://119.78.100.183/handle/2S10ELR8/290755]  
专题新药研究国家重点实验室
通讯作者Meng, Fanwang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, Shanghai, Peoples R China
2.McMaster Univ, Dept Chem & Chem Biol, Hamilton, ON L8S 4M1, Canada
3.Univ Chinese Acad Sci, Sch Pharm, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Fan, Shijie,Chen, Yu,Luo, Cheng,et al. Machine Learning Methods in Precision Medicine Targeting Epigenetic Diseases[J]. CURRENT PHARMACEUTICAL DESIGN,2018,24(34):3998-4006.
APA Fan, Shijie,Chen, Yu,Luo, Cheng,&Meng, Fanwang.(2018).Machine Learning Methods in Precision Medicine Targeting Epigenetic Diseases.CURRENT PHARMACEUTICAL DESIGN,24(34),3998-4006.
MLA Fan, Shijie,et al."Machine Learning Methods in Precision Medicine Targeting Epigenetic Diseases".CURRENT PHARMACEUTICAL DESIGN 24.34(2018):3998-4006.

入库方式： OAI收割

来源：上海药物研究所

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