Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same Glade
文献类型：期刊论文
| 作者 | Song, Hongshuo1; Ou, Weidong1; Feng, Yi1; Zhang, Junli1; Li, Fan1; Hu, Jing1; Peng, Hong1; Xing, Hui1; Ma, Liying1; Tan, Qiuxiang2 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2019-01-02 |
| 卷号 | 116期号:1页码:239-244 |
| 关键词 | CRF01_AE Coreceptor tropism CXCR4 CD4 count HIV-1 pathogenesis |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.1814714116 |
| 通讯作者 | Shao, Yiming(yshao@bjmu.edu.cn) |
| 英文摘要 | HIV-1 evolved into various genetic subtypes and circulating recombinant forms (CRFs) in the global epidemic. The same subtype or CRF is usually considered to have similar phenotype. Being one of the world's major CRFs, CRF01_AE infection was reported to associate with higher prevalence of CXCR4 (X4) viruses and faster CD4 decline. However, the underlying mechanisms remain unclear. We identified eight phylogenetic clusters of CRF01_AE in China and hypothesized that they may have different phenotypes. In the National HIV Molecular Epidemiology Survey, we discovered that people infected by CRF01_AE cluster 4 had significantly lower CD4 counts (391 vs. 470, P < 0.0001) and higher prevalence of X4-using viruses (17.1% vs. 4.4%, P < 0.0001) compared with those infected by cluster 5. In an MSM cohort, X4-using viruses were only isolated from seroconvertors in cluster 4, which was associated with low a CD4 count within the first year of infection (141 vs. 440, P = 0.003). Using a coreceptor binding model, we identified unique V3 signatures in cluster 4 that favor CXCR4 use. We demonstrate that the HIV-1 phenotype and pathogenicity can be determined at the phylogenetic cluster level in the same subtype. Since its initial spread to humans from chimpanzees, estimated to be the first half of the 20th century, HIV-1 continues to undergo rapid evolution in larger and more diverse populations. The divergent phenotype evolution of two major CRF01_AE clusters highlights the importance of monitoring the genetic evolution and phenotypic shift of HIV-1 to provide early warning of the appearance of more pathogenic strains. |
| WOS关键词 | HUMAN-IMMUNODEFICIENCY-VIRUS ; SYNCYTIUM-INDUCING PHENOTYPE ; CORECEPTOR USE ; BIOLOGICAL PHENOTYPE ; EXPERIENCED PATIENTS ; DISEASE PROGRESSION ; PROGNOSTIC VALUE ; E INFECTION ; TYPE-1 ; CCR5 |
| 资助项目 | China National Major Project for Infectious Diseases Control and Prevention ; China Key Project of the State Key Laboratory of Infectious Diseases Control and Prevention ; National Natural Science Foundation of China[NSFC31730027] ; National Natural Science Foundation of China[NSFC8171101312] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000454707700039 |
| 出版者 | NATL ACAD SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290807]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shao, Yiming |
| 作者单位 | 1.Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Ctr AIDS STD Control & Prevent, Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Chaoyang Ctr Dis Control & Prevent, Beijing 100021, Peoples R China 4.Peking Univ, Ctr Infect Dis, Beijing 100191, Peoples R China 5.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Hongshuo,Ou, Weidong,Feng, Yi,et al. Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same Glade[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(1):239-244. |
| APA | Song, Hongshuo.,Ou, Weidong.,Feng, Yi.,Zhang, Junli.,Li, Fan.,...&Shao, Yiming.(2019).Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same Glade.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(1),239-244. |
| MLA | Song, Hongshuo,et al."Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same Glade".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.1(2019):239-244. |
入库方式： OAI收割
来源：上海药物研究所
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