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A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei

文献类型：期刊论文

作者Feng, Lu5; Mandi, Attila3; Tang, Chunping2,5; Kurtan, Tibor3; Tang, Shuai4; Ke, Chang-Qiang2,5; Shen, Ning4; Lin, Ge2; Yao, Sheng2,5; Ye, Yang1,2,5
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2018-12-01
卷号81期号:12页码:2667-2672
ISSN号0163-3864
DOI10.1021/acs.jnatprod.8b00482
通讯作者Yao, Sheng(yaosheng@simm.ac.cn) ; Ye, Yang()
英文摘要(+/-)-Cryptomeriolide, a pair of racemic bis-seco-abietane diterpenoids, were isolated from the bark of Cryptomeria fortunei. The separation of enantiomers was achieved by using chiral stationary phase HPLC. Their structures including the absolute configuration and conformations in solution and solid state were determined by extensive analysis of spectroscopic data, single-crystal X-ray diffraction, and comparison of calculated and experimental electronic circular dichroism data. A bioinspired one-pot enantiomeric synthesis of 1a and 1b was accomplished via a readily made intermediate orthoquinone from sugiol. All compounds including the synthetic intermediates were assayed for their cytotoxic activities on human cancer cell lines HL-60, A549, and SGC7901.
WOS关键词ABSOLUTE-CONFIGURATION ; LEAVES ; BARK
资助项目National Science & Technology Major Project of China Key New Drug Creation and Manufacturing Program[2015ZX09103002] ; National Natural Science Foundation of China[81473112] ; National Natural Science Foundation of China[81573305] ; International Partnership Program of the Chinese Academy of Sciences[153631KYSB20160004] ; National Research, Development and Innovation Office[NKFI K120181] ; National Research, Development and Innovation Office[PD121020]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000454962500008
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/290860]  
专题中国科学院上海药物研究所
通讯作者Yao, Sheng; Ye, Yang
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
2.SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Shanghai 201203, Peoples R China
3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary
4.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Chem Dept, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Lu,Mandi, Attila,Tang, Chunping,et al. A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(12):2667-2672.
APA Feng, Lu.,Mandi, Attila.,Tang, Chunping.,Kurtan, Tibor.,Tang, Shuai.,...&Ye, Yang.(2018).A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei.JOURNAL OF NATURAL PRODUCTS,81(12),2667-2672.
MLA Feng, Lu,et al."A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei".JOURNAL OF NATURAL PRODUCTS 81.12(2018):2667-2672.

入库方式： OAI收割

来源：上海药物研究所

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