Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities
文献类型：期刊论文
| 作者 | Jin, Qinghao2; Hu, Xinyi1,2; Deng, Yanping2; Hou, Jinjun2 ; Lei, Min2; Ji, Hongjian2; Zhou, Jing2; Qu, Hua2; Wu, Wanying2; Guo, Dean2
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 23期号:12页码:8 |
| 关键词 | Salvia miltiorrhiza depsides nerve-protection HS-SY5Y |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules23123274 |
| 通讯作者 | Wu, Wanying(wanyingwu@simm.ac.cn) ; Guo, Dean(daguo@simm.ac.cn) |
| 英文摘要 | By investigating of the roots of Salvia miltiorrhiza, which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides (1-4) that were previously undescribed, along with eight known ones (5-12). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (H-1, C-13, HSQC, HMBC) data analyses. These four newly isolated compounds (1-4), as well as the other eight compounds (5-12), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells. Among them, depside 4 and depside 6 displayed more obviously protective effects than others. |
| WOS关键词 | ACID-B ; OXIDATIVE STRESS ; APOPTOSIS ; INJURY ; DAMAGE ; CELLS |
| 资助项目 | National Standardization of Traditional Chinese Medicine Project[ZYBZH-C-SH-49] ; National Natural Science Foundation of China[81530095] ; National Standardization Program for Chinese Medicine[ZYBZH-K-LN-01] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000454523000224 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290880]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Wanying; Guo, Dean |
| 作者单位 | 1.Zhejiang Univ Technol, Inst Bioengn, Hangzhou 310014, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Qinghao,Hu, Xinyi,Deng, Yanping,et al. Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities[J]. MOLECULES,2018,23(12):8. |
| APA | Jin, Qinghao.,Hu, Xinyi.,Deng, Yanping.,Hou, Jinjun.,Lei, Min.,...&Guo, Dean.(2018).Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities.MOLECULES,23(12),8. |
| MLA | Jin, Qinghao,et al."Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities".MOLECULES 23.12(2018):8. |
入库方式： OAI收割
来源：上海药物研究所
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