Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects
文献类型：期刊论文
| 作者 | Cheng, Tao3; Qu, Haiyun2; Zhang, Guoyou1; Zhang, Xianlong3 |
| 刊名 | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 46期号:8页码:1935-1947 |
| 关键词 | Mesoporous bioactive glass infection antimicrobial osteogenesis osteomyelitis |
| ISSN号 | 2169-1401 |
| DOI | 10.1080/21691401.2017.1396997 |
| 通讯作者 | Cheng, Tao(dr_tao.cheng@hotmail.com) |
| 英文摘要 | Chronic osteomyelitis and infected bone defects are substantial challenges faced by orthopaedic surgeons. In this study, vancomycin was loaded into mesoporous bioactive glass (MBG) to form a local antibiotic delivery system and then a bone tissue-engineering scaffold combining MBG and poly-(L-lactic-co-glycolic acid) (PLGA) was prepared by freeze-drying fabrication. In vitro degradation and water contact angle analysis suggested that the MBG-incorporated PLGA scaffold exhibited controlled degradability, stabilizing the pH of the surrounding environment and improved the hydrophilicity. Moreover, the presence of MBG provides a well-interconnected pore structure, to which human bone marrow-derived mesenchymal stem cells can attach, spread and proliferate, promoting upregulation of the expression of osteogenic markers. Thus, MBG/PLGA scaffolds exhibit better cytocompatibility and osteoblastic difierentiation properties compared with pure PLGA scaffolds. Vancomycin-loaded scaffolds have been found to yield sustained release that lasts for more than eight weeks in vitro. We tested the antibacterial performance of vancomycin-loaded scaffolds against Staphylococcus aureus, the most common bacteria isolated from infected bone. In vitro experiments demonstrated that loading vancomycin onto the scaffold promoted antibacterial activity and inhibited biofilm formation without deleterious effect on cytocompatibility. In conclusion, the novel inorganic-organic composites are considered potential materials for the treatment of infected bone defects. |
| WOS关键词 | BIOACTIVE GLASS SCAFFOLDS ; IN-VITRO ; DELIVERY ; MICROSPHERES ; BIOMATERIALS |
| 资助项目 | National Natural Science Foundation of China[81301571] ; Shanghai Municipal Health and Family Planning Commission for Distinguished Young Doctors[20141032] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000452031000039 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/290901]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Cheng, Tao |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, Anal & Testing Ctr Inorgan Mat, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Dept Orthopaed Surg, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Tao,Qu, Haiyun,Zhang, Guoyou,et al. Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2018,46(8):1935-1947. |
| APA | Cheng, Tao,Qu, Haiyun,Zhang, Guoyou,&Zhang, Xianlong.(2018).Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,46(8),1935-1947. |
| MLA | Cheng, Tao,et al."Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46.8(2018):1935-1947. |
入库方式： OAI收割
来源：上海药物研究所
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