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Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy

文献类型：期刊论文

作者Liu, Yamei1,2,3; Shen, Guizhi3; Zhao, Luyang3; Zou, Qianli3; Jiao, Tifeng1,2; Yan, Xuehai3,4,5
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2019-11-13
卷号11期号:45页码:41898-41905
关键词photothermal nanoparticle peptide genipin covalent assembly tumor therapy
ISSN号1944-8244
DOI10.1021/acsami.9b13966
英文摘要Photothermal nanodrugs based on biomolecules are critically important for advancing photothermal therapy (PTT). However, constructing photothermal nano drugs from biomolecules is highly challenging because most biomolecules are inherently nonpigmented. Herein, we synthesize well-defined, uniform photothermal nanodrugs through a covalent assembly approach by using nonpigmented peptides and iridoids as building blocks. The resulting photothermal nanodrugs show broad absorption from the UV to the near-infrared region, high photothermal conversion efficiency along with robust photostability, and selective tumor accumulation, leading to highly efficient tumor ablation via PTT. This work represents the first example of photothermal nanodrugs that can be constructed by using nonpigmented biomolecules as building blocks and thus will conceivably promote the preclinical evaluation and clinical translation of PTT.
WOS关键词PHOTODYNAMIC THERAPY ; CROSS-LINKING ; NANOPARTICLES ; PHOTOSENSITIZERS ; CAPABILITIES ; NANOSPHERES ; GENIPIN ; DESIGN
资助项目National Natural Science Foundation of China[21603233] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Youth Innovation Promotion Association CAS[2019051]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000497263600007
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS
源URL[http://ir.ipe.ac.cn/handle/122111/38298]  
专题中国科学院过程工程研究所
通讯作者Zou, Qianli; Jiao, Tifeng; Yan, Xuehai
作者单位1.Yanshan Univ, Sch Environm & Chem Engn, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Hebei, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Yamei,Shen, Guizhi,Zhao, Luyang,et al. Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(45):41898-41905.
APA Liu, Yamei,Shen, Guizhi,Zhao, Luyang,Zou, Qianli,Jiao, Tifeng,&Yan, Xuehai.(2019).Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy.ACS APPLIED MATERIALS & INTERFACES,11(45),41898-41905.
MLA Liu, Yamei,et al."Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy".ACS APPLIED MATERIALS & INTERFACES 11.45(2019):41898-41905.

入库方式： OAI收割

来源：过程工程研究所

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