Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer
文献类型：期刊论文
| 作者 | Ye, Zhou1; Hua, Dong3; Rao, Yijian1; Bai, Shuo4; Seeberger, Peter H.5; Yin, Jian1; Hu, Jing2 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2020-01-20 |
| 卷号 | 585页码:8 |
| 关键词 | Cercosporin Multifunctional copolymer Targeted photodynamic therapy Photosensitizer |
| ISSN号 | 0927-7757 |
| DOI | 10.1016/j.colsurfa.2019.124136 |
| 英文摘要 | Photoactivated perylenequinones are photosensitizers that transfer into reactive oxygen species with light energy for photodynamic therapy (PDT). Novel photoactivated perylenequinones photosensitizers are of current interest for application in PDT. Cercosporin, a new photoactivated perylenequinone photosensitizer, was encapsulated into multifunctional copolymer for targeting hepatocellular carcinoma cells to give enhanced PDT efficiency. The cercosporin encapsulated multifunctional copolymer exhibited higher targeting ability and better PDT efficiency to HepG2 cells compared with non-targeting copolymer system. Z-stack technique was used to monitor the cytoplasm distribution of cercosporin. The multifunctional copolymer can release cercosporin only in acidic tumor microenvironment to induce a PDT effect and realize the tracking ability thanks to covalent binding with rhodamine B. The cercosporin encapsulated multifunctional copolymer holds great potential in PDT for cancer treatment. |
| WOS关键词 | SINGLET OXYGEN ; RADICAL POLYMERIZATION ; RHODAMINE-B ; DERIVATIVES ; EFFICIENT ; MICELLES |
| 资助项目 | National Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; High-end Foreign Experts Recruitment Program ; Thousand Talents Plan (Young Professionals) ; China Scholarship Council |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000502046200069 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; High-end Foreign Experts Recruitment Program ; Thousand Talents Plan (Young Professionals) ; China Scholarship Council |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/38445]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yin, Jian; Hu, Jing |
| 作者单位 | 1.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China 2.Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China 3.Jiangnan Univ, Affiliated Hosp, Wuxi 214122, Jiangsu, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China 5.Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, Muhlenberg 1, D-14476 Potsdam, Germany |
| 推荐引用方式 GB/T 7714 | Ye, Zhou,Hua, Dong,Rao, Yijian,et al. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,585:8. |
| APA | Ye, Zhou.,Hua, Dong.,Rao, Yijian.,Bai, Shuo.,Seeberger, Peter H..,...&Hu, Jing.(2020).Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,585,8. |
| MLA | Ye, Zhou,et al."Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 585(2020):8. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。