Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair
文献类型：期刊论文
| 作者 | Hu, Xueyan2; Xu, Jie2; Li, Wenfang2,3; Li, Liying2; Parungao, Roxanne4; Wang, Yiwei4; Zheng, Shuangshuang1; Nie, Yi1,5; Liu, Tianqing2; Song, Kedong2 |
| 刊名 | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
 |
| 出版日期 | 2019-12-21 |
| 页码 | 25 |
| ISSN号 | 0273-2289 |
| 关键词 | Layered scaffold Cell Bioreactor Tissue engineering Osteochondral repair |
| DOI | 10.1007/s12010-019-03214-8 |
| 英文摘要 | Repairing osteochondral defects to restore joint function is a major challenge in regenerative medicine. However, with recent advances in tissue engineering, the development of potential treatments is promising. In recent years, in addition to single-layer scaffolds, double-layer or multilayer scaffolds have been prepared to mimic the structure of articular cartilage and subchondral bone for osteochondral repair. Although there are a range of different cells such as umbilical cord stem cells, bone marrow mesenchyml stem cell, and others that can be used, the availability, ease of preparation, and the osteogenic and chondrogenic capacity of these cells are important factors that will influence its selection for tissue engineering. Furthermore, appropriate cell proliferation and differentiation of these cells is also key for the optimal repair of osteochondral defects. The development of bioreactors has enhanced methods to stimulate the proliferation and differentiation of cells. In this review, we summarize the recent advances in tissue engineering, including the development of layered scaffolds, cells, and bioreactors that have changed the approach towards the development of novel treatments for osteochondral repair. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; ARTICULAR-CARTILAGE DEFECTS ; TRANSFORMING-GROWTH-FACTOR ; HYBRID HYDROGEL SCAFFOLD ; COLLAGEN-BASED SCAFFOLD ; PROOF-OF-CONCEPT ; PROGENITOR CELLS ; INTRAARTICULAR INJECTION ; BONE-FORMATION ; AUTOLOGOUS TRANSPLANTATION |
| 资助项目 | National Natural Science Foundation of China[31670978/31370991/21676041] ; Fok Ying Tung Education Foundation[132027] ; State Key Laboratory of Fine Chemicals[KF1111] ; Natural Science Foundation of Liaoning[20180510028] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000503663300002 |
| 资助机构 | National Natural Science Foundation of China ; Fok Ying Tung Education Foundation ; State Key Laboratory of Fine Chemicals ; Natural Science Foundation of Liaoning |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/38550]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Nie, Yi; Liu, Tianqing; Song, Kedong |
| 作者单位 | 1.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Henan, Peoples R China 2.Dalian Univ Technol, Dalian R&D Ctr Stem Cell & Tissue Engn, Stale Key Lab Fine Chem, Dalian 116024, Peoples R China 3.Weifang Med Univ, Univ Shandong Prov Weifang Key Lab Antibody Med, Sch Biosci & Technol, Key Lab Biol Med, Weifang 261053, Peoples R China 4.Univ Sydney, Burns Res Grp, ANZAC Res Inst, Concord, NSW 2139, Australia 5.Chinese Acad Sci, Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xueyan,Xu, Jie,Li, Wenfang,et al. Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair[J]. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2019:25. |
| APA | Hu, Xueyan.,Xu, Jie.,Li, Wenfang.,Li, Liying.,Parungao, Roxanne.,...&Song, Kedong.(2019).Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair.APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,25. |
| MLA | Hu, Xueyan,et al."Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair".APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2019):25. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。