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Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting

文献类型：期刊论文

作者Jian, Honglei1; Wang, Meiyue1; Dong, Qjanqian1; Li, Jieling1; Wang, Anhe1; Li, Xin1; Ren, Peng1; Bai, Shuo1,2
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2019-12-18
卷号11期号:50页码:46419-46426
ISSN号1944-8244
关键词peptide hydrogel 3D bioprinting mechanical property tumor spheroid
DOI10.1021/acsami.9b13905
英文摘要Supramolecular hydrogels self-assembled from short peptides have shown great potential as biomimetic extracellular matrices with controllable properties designed at the molecular level. However, their weak mechanical strength still remains a big challenge for 3D bioprinting. Herein, two oppositely charged dipeptides are designed and used as bioinks in a "layer-by-layer" alternative bioprinting strategy. During printing, in situ gelation is achieved by electrostatic interactions between two dipeptides without additional cross-linking procedures. The binary hydrogels have tunable mechanical properties with elastic moduli ranging from 4 to 62 kPa and controllable biodegradability from days to weeks, which can ideally mimic the natural environment of a variety of cell types. It is demonstrated that the hydrogel scaffold enables the formation, growth, and natural release of HepaRG spheroids with sizes up to millimeters. This strategy may be suitable to develop a series of new bioink materials based on peptides and other supramolecular polymers for 3D bioprinting.
WOS关键词BETA-SHEET ; CELL-CULTURE ; PEPTIDE ; BIOINK ; SCAFFOLDS ; STIFFNESS ; DESIGN ; CHARGE
资助项目National Natural Science Foundation of China[21774132] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020206]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000503918300003
资助机构National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/38586]  
专题中国科学院过程工程研究所
通讯作者Bai, Shuo
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Jian, Honglei,Wang, Meiyue,Dong, Qjanqian,et al. Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(50):46419-46426.
APA Jian, Honglei.,Wang, Meiyue.,Dong, Qjanqian.,Li, Jieling.,Wang, Anhe.,...&Bai, Shuo.(2019).Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting.ACS APPLIED MATERIALS & INTERFACES,11(50),46419-46426.
MLA Jian, Honglei,et al."Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting".ACS APPLIED MATERIALS & INTERFACES 11.50(2019):46419-46426.

入库方式： OAI收割

来源：过程工程研究所

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