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Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System

文献类型：期刊论文

作者Lu, Zhiguo2,4; Zhang, Tianlu2,4; Wang, Xiangyu2; Wang, Jianze2; Shen, Jie2,4; Xiao, Zuobing1,5; Chen, Lei3; Zhang, Xin2
刊名ACS BIOMATERIALS SCIENCE & ENGINEERING
出版日期2020
卷号6期号:1页码:442-449
关键词zwitterionic polymer-based nanoparticles encapsulation of fragrance adhesion of fragrance sustained and pH-sensitive release of fragrance regulation of central nervous system
ISSN号2373-9878
DOI10.1021/acsbiomaterials.9b01451
英文摘要Aromatherapy is widely used in the treatment of diseases of the central nervous system, such as depression and anxiety. However, the rapid and uncontrolled release of aroma weakens the effects of aromatherapy. In this study, zwitterionic polymer-based nanoparticles encapsulated with linalool were prepared to improve the regulation of the central nervous system. First, the nanoparticles were modified with positive charges to adhere to the surface of silk via electrostatic interactions between the cationic nanoparticles and anionic silk. Besides, the fragrance was sustainably and controllably released from the nanoparticles. The effects of polymerization degree, polymer structure, and zeta potential on encapsulation efficiency, adhesion efficiency, and release profiles of linalool were then explored. The results showed that the linalool-encapsulated nanoparticles had the best performances of encapsulation, adhesion and release of fragrance when the polymerization degrees of hydrophilic block and hydrophobic block were 20 and 5, respectively. In addition, open field tests evaluated the regulation of nanoparticles on the central nervous system at the behavioral level. Measurements of dopamine, acetylcholine, and gamma-aminobutyric acid expressions explored the mechanism of moderating effects on the central nervous system at the molecular level.
WOS关键词FRAGRANCE ; LIPOSOMES ; DELIVERY ; ACETYLCHOLINE ; MODULATION ; DISEASE ; ABILITY ; ACID
资助项目National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[51573188] ; Beijing Municipal Science & Technology Commission[Z161100002616015]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000507429200040
出版者AMER CHEMICAL SOC
资助机构National High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission
源URL[http://ir.ipe.ac.cn/handle/122111/38785]  
专题中国科学院过程工程研究所
通讯作者Xiao, Zuobing; Chen, Lei; Zhang, Xin
作者单位1.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Navy Gen Hosp People Liberat Army, Dept Obstet & Gynecol, Beijing 100048, Peoples R China
4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
5.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Zhiguo,Zhang, Tianlu,Wang, Xiangyu,et al. Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(1):442-449.
APA Lu, Zhiguo.,Zhang, Tianlu.,Wang, Xiangyu.,Wang, Jianze.,Shen, Jie.,...&Zhang, Xin.(2020).Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(1),442-449.
MLA Lu, Zhiguo,et al."Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.1(2020):442-449.

入库方式： OAI收割

来源：过程工程研究所

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