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Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy

文献类型：期刊论文

作者Yang, Mengyao1,3; Yuan, Chengqian1; Shen, Guizhi1; Chang, Rui1,3; Xing, Ruirui1; Yan, Xuehai1,2,3
刊名JOURNAL OF COLLOID AND INTERFACE SCIENCE
出版日期2019-12-01
卷号557页码:458-464
ISSN号0021-9797
关键词Cyclic dipeptide Nanoribbon Self-assembly Dye Tumor therapy
DOI10.1016/j.jcis.2019.09.049
英文摘要Cyclic dipeptides (CDPs), the smallest naturally occurring cyclic peptides, have attracted tremendous attention due to their exceptional biological and pharmacological activities such as antitumor, antimicrobial, and immune regulation. However, controlled fabrication of CDPs nanostructures to address the problem of poor aqueous solubility and low bioavailability existing in therapeutic application is still in challenging, due to their remarkable structural rigidity and superior hydrogen-bonding-forming capability. Herein, a simple but robust and universal strategy for the construction of CDP nanoribbons based on the amphiphilic dye-mediated hydrophobic self-assembly is presented. The amphiphilic dyes not only provide the robust hydrophobic interaction for the formation of CDP nanoribbons but also offer enough electrostatic repulsion forces to stabilize the formed assemblies. Moreover, the introduction of functional dyes endows the assembled CDP nanoribbons multiple benign therapeutic features, including adjustable shape and size, improved bioavailability, as well as preferable cellular uptake and biodistribution, thereby enhanced chemotherapy efficacy in vitro and in vivo. The strategy developed based on the dye-mediated self-assembly provides a promising way to rationally design water-insoluble bioactive CDPs for therapeutic applications. (C) 2019 Elsevier Inc. All rights reserved.
WOS关键词BUILDING-BLOCKS ; RATIONAL DESIGN ; NANOSTRUCTURES ; TRANSFORMATION ; AMPHIPHILES ; DERIVATIVES ; FABRICATION ; PEPTIDES ; GELATION ; FORCE
资助项目National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21603233] ; National Natural Science Foundation of China[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS研究方向Chemistry
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:000494056200045
资助机构National Natural Science Foundation of China ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
源URL[http://ir.ipe.ac.cn/handle/122111/39026]  
专题中国科学院过程工程研究所
通讯作者Yan, Xuehai
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Mengyao,Yuan, Chengqian,Shen, Guizhi,et al. Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,557:458-464.
APA Yang, Mengyao,Yuan, Chengqian,Shen, Guizhi,Chang, Rui,Xing, Ruirui,&Yan, Xuehai.(2019).Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,557,458-464.
MLA Yang, Mengyao,et al."Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 557(2019):458-464.

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来源：过程工程研究所

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