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Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy

文献类型：期刊论文

作者Sun, Haifeng3,4; Chang, Rui1,3; Zou, Qianli3; Xing, Ruirui3; Qi, Wei4; Yan, Xuehai1,2,3
刊名SMALL
出版日期2019-10-28
页码7
关键词albumin nanodrugs pheophorbide a photothermal therapy self-assembly
ISSN号1613-6810
DOI10.1002/smll.201905326
英文摘要Supramolecular protein nanodrugs provide opportunities for improving antitumor therapeutic efficiency and lowering toxicity. However, protein nanodrugs that have robust structural stability and enhanced therapeutic efficiency are still in infancy. In this study, photothermal protein nanodrugs are constructed through a supramolecular approach along with heating by using proteins, photosensitizers, and metal ions as the building blocks. The metal coordination and heating improve not only the structural stability but also photothermal performance of the resulting nanodrugs. By virtue of the first integration of coordination- and heating-enhanced photothermal effects, the nanodrugs show superior photothermal conversion efficiency, enhanced tumor accumulation, and improved tumor inhibition. Metal coordination and heating are versatile to be applied for various protein nanodrugs. Hence, this study provides insights for the construction of highly efficient photothermal nanodrugs and thus will be beneficial to precision theranostics.
WOS关键词SERUM-ALBUMIN NANOPARTICLES ; CANCER-THERAPY ; PHOTODYNAMIC THERAPY ; THERMAL-DENATURATION ; IN-VITRO ; DELIVERY ; HYDROPHOBICITY ; THERANOSTICS ; PHEOPHORBIDE ; GRAPHENE
资助项目National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000492739800001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
源URL[http://ir.ipe.ac.cn/handle/122111/39059]  
专题中国科学院过程工程研究所
通讯作者Zou, Qianli; Qi, Wei; Yan, Xuehai
作者单位1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Haifeng,Chang, Rui,Zou, Qianli,et al. Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy[J]. SMALL,2019:7.
APA Sun, Haifeng,Chang, Rui,Zou, Qianli,Xing, Ruirui,Qi, Wei,&Yan, Xuehai.(2019).Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy.SMALL,7.
MLA Sun, Haifeng,et al."Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy".SMALL (2019):7.

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来源：过程工程研究所

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