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Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly

文献类型：期刊论文

作者Song, Jingwen1,2; Yuan, Chengqian1; Jiao, Tifeng2; Xing, Ruirui1; Yang, Mengyao1,3; Adams, Dave J.4; Yan, Xuehai1,3,5
刊名SMALL
出版日期2020-02-01
卷号16期号:8页码:10
关键词amino acids antimicrobial biometallohydrogels broad-spectrum coordinated self-assembly
ISSN号1613-6810
DOI10.1002/smll.201907309
英文摘要There is a real need for new antibiotics against self-evolving bacteria. One option is to use biofriendly broad-spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug-resistant microbes. Whilst appealing, there are currently limited options. Herein, broad-spectrum antimicrobial biometallohydrogels based on the self-assembly and local mineralization of Ag+-coordinated Fmoc-amino acids are reported. Such biometallohydrogels have the advantages of localized delivery and sustained release, reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. Furthermore, they can directly interact with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm. This leads to cell death, triggering a significant antibacterial effect against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria in cells and mice. This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self-assembly toward a broad range of biomedical applications.
WOS关键词STAPHYLOCOCCUS-AUREUS ; CATIONIC POLYMERS ; SILVER ; PEPTIDES ; HYDROGEL ; NANOARCHITECTONICS ; NANOSTRUCTURES ; NANOPARTICLES ; NANOCLUSTERS ; ANTIBIOTICS
资助项目National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005] ; EPSRC[EP/L021978/1]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000511243900001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative ; EPSRC
源URL[http://ir.ipe.ac.cn/handle/122111/39211]  
专题中国科学院过程工程研究所
通讯作者Jiao, Tifeng; Adams, Dave J.; Yan, Xuehai
作者单位1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland
5.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Song, Jingwen,Yuan, Chengqian,Jiao, Tifeng,et al. Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly[J]. SMALL,2020,16(8):10.
APA Song, Jingwen.,Yuan, Chengqian.,Jiao, Tifeng.,Xing, Ruirui.,Yang, Mengyao.,...&Yan, Xuehai.(2020).Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly.SMALL,16(8),10.
MLA Song, Jingwen,et al."Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly".SMALL 16.8(2020):10.

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来源：过程工程研究所

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