NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy
文献类型：期刊论文
| 作者 | Xi, Dongmei2; Xiao, Ming2; Cao, Jianfang2; Zhao, Luyang1; Xu, Ning2; Long, Saran2; Fan, Jiangli2; Shao, Kun2; Sun, Wen2; Yan, Xuehai1 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2020-02-05 |
| 页码 | 8 |
| 关键词 | barrier-free rotation NIR light photothermal therapy polymeric nanoparticles safe intensity light |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201907855 |
| 英文摘要 | Traditional photothermal therapy requires high-intensity laser excitation for cancer treatments due to the low photothermal conversion efficiency (PCE) of photothermal agents (PTAs). PTAs with ultra-high PCEs can decrease the required excited light intensity, which allows safe and efficient therapy in deep tissues. In this work, a PTA is synthesized with high PCE of 88.3% based on a BODIPY scaffold, by introducing a -CF3 "barrier-free" rotor on the meso-position (tfm-BDP). In both the ground and excited state, the -CF3 moiety in tfm-BDP has no energy barrier to rotation, allowing it to efficiently dissipate absorbed (NIR) photons as heat. Importantly, the barrier-free rotation of -CF3 can be maintained after encapsulating tfm-BDP into polymeric nanoparticles (NPs). Thus, laser irradiation with safe intensity (0.3 W cm(-2), 808 nm) can lead to complete tumor ablation in tumor-bearing mice after intravenous injection of tfm-BDP NPs. This strategy of "barrier-free rotation" provides a new platform for future design of PTT agents for clinical cancer treatment. |
| WOS关键词 | AGGREGATION ; SQUARAINE ; VESICLES ; SENSOR ; AGENT |
| 资助项目 | National Natural Science Foundation of China[21808028] ; National Natural Science Foundation of China[21576037] ; National Natural Science Foundation of China[21421005] ; Science and Technology Foundation of Liaoning Province[2019-BS-047] ; Fundamental Research Funds for the Central Universities[2018011013] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000511035300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China ; Science and Technology Foundation of Liaoning Province ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/39260]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Sun, Wen; Peng, Xiaojun |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xi, Dongmei,Xiao, Ming,Cao, Jianfang,et al. NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy[J]. ADVANCED MATERIALS,2020:8. |
| APA | Xi, Dongmei.,Xiao, Ming.,Cao, Jianfang.,Zhao, Luyang.,Xu, Ning.,...&Peng, Xiaojun.(2020).NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy.ADVANCED MATERIALS,8. |
| MLA | Xi, Dongmei,et al."NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy".ADVANCED MATERIALS (2020):8. |
入库方式： OAI收割
来源：过程工程研究所
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