Self-Assembling Proteins for Design of Anticancer Nanodrugs
文献类型：期刊论文
| 作者 | Zou, Qianli1; Chang, Rui1; Yan, Xuehai1,2 |
| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2020-03-31 |
| 页码 | 16 |
| ISSN号 | 1861-4728 |
| 关键词 | Protein Self-assembly Intermolecular interactions Nanodrugs Cancer therapy |
| DOI | 10.1002/asia.202000135 |
| 英文摘要 | Inspired by the diverse protein-based structures and materials in organisms, proteins have been expected as promising biological components for constructing nanomaterials toward various applications. In numerous studies protein-based nanomaterials have been constructed with the merits of abundant bioactivity and good biocompatibility. However, self-assembly of proteins as a dominant approach in constructing anticancer nanodrugs has not been reviewed. Here, we provide a comprehensive account of the role of protein self-assembly in fabrication, regulation, and application of anticancer nanodrugs. The supramolecular strategies, building blocks, and molecular interactions of protein self-assembly as well as the properties, functions, and applications of the resulting nanodrugs are discussed. The applications in chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy, gene therapy, and combination therapy are included. Especially, manipulation of molecular interactions for realizing cancer-specific response and cancer theranostics are emphasized. By expounding the impact of molecular interactions on therapeutic activity, rational design of highly efficient protein-based nanodrugs for precision anticancer therapy can be envisioned. Also, the challenges and perspectives in constructing nanodrugs based on protein self-assembly are presented to advance clinical translation of protein-based nanodrugs and next-generation nanomedicine. |
| WOS关键词 | HUMAN SERUM-ALBUMIN ; DRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; GOLD NANOPARTICLE ; BOUND PACLITAXEL ; CANCER-THERAPY ; THERANOSTICS ; TRANSFERRIN ; LIGAND ; HSA |
| 资助项目 | National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005] ; Youth Innovation Promotion Association CAS[2019051] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000522513000001 |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative ; Youth Innovation Promotion Association CAS |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/39905]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yan, Xuehai |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Qianli,Chang, Rui,Yan, Xuehai. Self-Assembling Proteins for Design of Anticancer Nanodrugs[J]. CHEMISTRY-AN ASIAN JOURNAL,2020:16. |
| APA | Zou, Qianli,Chang, Rui,&Yan, Xuehai.(2020).Self-Assembling Proteins for Design of Anticancer Nanodrugs.CHEMISTRY-AN ASIAN JOURNAL,16. |
| MLA | Zou, Qianli,et al."Self-Assembling Proteins for Design of Anticancer Nanodrugs".CHEMISTRY-AN ASIAN JOURNAL (2020):16. |
入库方式： OAI收割
来源：过程工程研究所
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